秦岭柴胡抗大鼠肝纤维化的研究  

Study on the effect of Bupleurum longicayle wall.es DC.var.giradii wolff on rats hepatic fibrosis

作　　者：刘阿萍[1] 景万燕 李敏[1] 

机构地区：[1]陕西中医学院药学院,咸阳712046 [2]榆林市横山县卫生局,横山719200

出　　处：《中药药理与临床》2012年第5期122-124,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：陕西省中管局课题(zy06);陕西省教育厅项目(12JK1016)

摘　　要：目的:观察秦岭柴胡水煎液对复合因素所致大鼠肝纤维化的作用。方法:制备四氯化碳、酒精以及高脂饲料等复合因素所致肝纤维化模型,将24只大鼠,随机分为:秦岭柴胡水煎液组,肝纤维化模型组,空白对照组。给药组连续7天灌胃秦岭柴胡水煎液(5.6g/kg),观察秦岭柴胡水煎液对肝纤维化大鼠血清中谷草转氨酶(AST)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)的影响,探讨秦岭柴胡抗肝纤维化效应。结果:秦岭柴胡水煎液(5.6g/kg)能抑制实验性肝纤维化大鼠血清中AST、HA、PCⅢ、Ⅳ-C水平的升高。结论:秦岭柴胡水煎液对实验性肝纤维化有一定的治疗作用。Objective：To study the effect of aqueous extract of Bupleurum longicayle wall.es DC.var.giradii wolff（AEBG） against complex factors induced liver fibrosis model in mice.Methods：To preparation liver fibrosis in mice by alcohol、CCl4 and high fat feed factors,then the contents of AST,HA,PCⅢ,Ⅳ-C in serum were measured.Results：The contents of AST,HA,PCⅢ,Ⅳ-C in serum was decreased in the mice that treatment with AEBG.Conclusion：aqueous extract of Bupleurum longicayle wall.es DC.var.giradii wolff（0.5ml/100g） have a therapeutic effect on liver fibrosis induced by alcohol and CCl4 in mice.

关 键 词：秦岭柴胡 水煎液 肝纤维化 

分 类 号：R285[医药卫生—中药学]