蔓菁抗疲劳作用的量效关系初步研究  

Study on the dose-effect relationship of the anti-fatigue effects in the ethnomedicine of Brassica rapa

作　　者：王张[1] 张艺[1] 周林[1] 杨永东[1] 王宇[1] 杨洋[1] 邝婷婷[1] 

机构地区：[1]成都中医药大学民族医药学院,成都611137

出　　处：《中药药理与临床》2012年第5期128-130,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金地区科学基金项目(30960507)

摘　　要：目的:初步揭示民族药蔓菁抗疲劳作用的量效关系。方法:采用"对数剂量设计法"设置蔓菁水提取物的不同剂量,观察其对小鼠室温游泳时间的影响。结果:蔓菁水提取物在376.20～37619.86 mg(蔓菁药材)/kg/次剂量范围内有明显的缓解体力疲劳的作用,其中376.20 mg(蔓菁药材)/kg/次剂量组小鼠的平均游泳时间最长,且明显优于阳性药红牛维生素功能饮料。结论:蔓菁水提取物在一定的剂量范围内具有明显的缓解体力疲劳作用,但是量效关系不成简单的正比关系。Objective：To preliminary study the dose-effect relationship of the anti-fatigue effects in the ethnomedicine of Brassica rapa.Methods：The logarithmic dose design method of the dose-effect relationship was applied by setting different dosages of the water extracts of Brassica rapa（WEB）,and the water extracts＇ influences on the mice swimming time were detected at room temperature.Results：The WEB 376.20～37619.86 mg（crude drug）/kg/dose had significant anti-fatigue effect（P0.05）.The mice giving WEB 376.20 mg（crude drug）/kg/dose had the longest swimming time,which was significantly better than the positive Red Bull group（P0.05）.Conclusion：The WEB had significant anti-fatigue effects in a certain dose range,but the dose-effect relationship is not the proportional relationship.

关 键 词：藏药 维药 蔓菁 抗疲劳 量效关系 

分 类 号：R285[医药卫生—中药学]