骨刺消巴布剂对兔膝骨性关节炎IL-1β和TNF-α的影响  

Effects of GuCiXiao Cataplasm on IL-1β and TNF-α of Rabbits with Knee Osteoarthritis

作　　者：赵军[1] 邢涛[1] 董林[1] 魏国俊[1] 雷宁波[1] 王志勇[1] 徐玉德[1] 

机构地区：[1]甘肃省中医院,甘肃兰州730050

出　　处：《西部中医药》2012年第11期25-27,共3页Western Journal of Traditional Chinese Medicine

基　　金：甘肃省中医药科学技术研究课题(编号GZK-2011-66)

摘　　要：目的:探讨骨刺消巴布剂对兔膝骨性关节炎模型关节液中IL-1β和TNF-α水平的影响。方法:选用健康日本大耳白兔40只,随机分为骨刺消巴布剂组(A组),奇正消痛贴组(B组),空白对照组(C组),正常组(D组)。A、B、C组通过改良经典的Videman固定法制备兔膝骨性关节炎模型,A、B组外敷相应药物,C、D组不做任何处理,于造模成功后第1天和药物治疗后第5周测关节液中IL-1β、TNF-α含量。结果:造模后A、B、C组IL-1β和TNF-α与D组比较显著高表达(P<0.01),而3组之间比较无统计学意义;治疗5周后,A组、B组与C组比较,IL-1β和TNF-α含量下降(P<0.05),C组IL-1β和TNF-α表达稍有下降,但无统计学意义。结论:骨刺消巴布剂可能通过降低关节液IL-1β和TNF-α的含量,对膝骨性关节炎起到治疗作用。Objective： To investigate the effect of GuCiXiao cataplasm on IL-1β and TNF-α in joint fluid of rabbits with knee osteoarthritis.Method： Forty rabbits were chosen and randomized into GuCiXiao cataplasm group（A group）,QiZheng XiaoTongTie group（B group）,blank control group（C group） and normal group（D group）.Rabbit models in groups of A,B and C were prepared with Videman fixation,A and B groups were applied with corresponding drugs externally,C and D groups were left unhandled,Contents of IL-1β and TNF-α in joint fluid were measured at the 1st day after successfully establishing the models and the fifth week after treating.Result： Expressions of IL-1β and TNF-α in A,B and C after establishing the models were higher than that of D（P0.01）,comparisons among A,B and C manifested no statistical meaning;after treating for five weeks,compared with C,contents of IL-1β and TNF-α decreased in A and B（P0.05）,expressions of IL-1β and TNF-α in C lowered slightly and the difference had no statistical meaning.Conclusion： GuCiXiao cataplasm could prevent knee osteoarthritis which might decrease the contents of IL-1β and TNF-α in joint fluid.

关 键 词：关节炎 膝骨性 骨刺消巴布剂 IL-1Β TNF-Α 

分 类 号：R285.5[医药卫生—中药学]