裴氏黄白散治疗易瑞沙所致皮肤不良反应的疗效观察  

Observation on Curative Effects of PeiShi HuangBaiSan in Treating Adverse Reaction of Skin Induced by Gefitinib Tablets

作　　者：邱玉梅[1] 

机构地区：[1]甘肃省肿瘤医院,甘肃兰州730050

出　　处：《西部中医药》2012年第11期80-82,共3页Western Journal of Traditional Chinese Medicine

摘　　要：目的:观察裴氏黄白散外敷治疗易瑞沙所致皮肤不良反应的临床疗效。方法:选取64例口服易瑞沙治疗后出现皮肤不良反应的非小细胞肺癌Ⅳ期患者,随机分为观察组和对照组各32例。观察组采用裴氏黄白散外敷,对照组采用复方醋酸地塞米松(皮炎平)涂擦,观察2组皮肤反应在第7天、第14天和第28天的治疗效果。结果:观察组在第7天总有效率为75.0%,对照组为78.1%,较对照组略低,但无显著性差异(P>0.05);观察组第14天和第28天治疗组总有效率均为100%,对照组第14天和第28天总有效率分别为81.3%、84.4%,观察组明显优于对照组(P<0.05)。结论:裴氏黄白散外敷治疗分子靶向药物所致皮肤不良反应,具有很好疗效,无明显副作用,不易产生耐药性。Objective： To approach curative effect of PeiShi HuangBaiSan applied to adverse reaction of skin externally induced by gefitinib tablets.Method： Sixty-four patients of Non-small-cell lung cancer（NSCLC） at stage Ⅳ who took gefitinib tablets and manifested serious adverse reaction were chosen and divided into observation group and control group equally.Observation group used PeiShi HuangBaiSan externally and control group were given with compound dexamethasone acetate cream（PiYanPing） externally.Curative effective of both groups were observed at the 7th,14th and 28th day.Result： Total effective rate of observation group was 75.0% at the 7th day,lower than 78.1% of control group but without significant difference（P0.05）;total effective rates of observation group were 100% at the 14th and 28th day,obviously superior to 81.3% and 84.4% of control group（P0.05）.Conclusion： PeiShi HuangBaiSan in treating adverse reaction of skin caused by molecule-targeting agents for external use is effective without remarkable side effects.

关 键 词：皮肤不良反应 裴氏黄白散 易瑞沙 治疗 临床研究性 护理 

分 类 号：R473[医药卫生—护理学]