口服益生菌联合丁酸氢化可的松乳膏等治疗婴儿湿疹临床观察  

Clinical Observations on Infant Eczema Treated with Probiotics and Hydrocortisone Butyrate Creama

作　　者：李丽萍[1] 卢淑娇[1] 陈美珍[1] 

机构地区：[1]浙江省丽水市人民医院皮肤科,浙江丽水323000

出　　处：《中国皮肤性病学杂志》2012年第12期1089-1090,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的 探讨肠道益生菌对婴儿湿疹的早期干预效果。方法 97例人工喂养湿疹患儿,随机分干预组和对照组。干预组48例,口服双歧三联活菌胶囊,连续6个月,有渗液时用0.1%盐酸小柴胡碱溶液湿敷,无渗液时用丁酸氢化可的松乳膏,伴感染时加用莫匹罗星软膏外涂,少数严重者给氯雷他定糖浆口服;对照组49例,除不用双歧三联活菌胶囊外,其余与干预组相同。每月通过门诊、电话或上门探视等方式观察记录湿疹病情,共6个月。结果 干预组湿疹发生率在第2个月为31.25%、第4个月27.08%、第6个月20.83%,发病程度逐渐减轻;对照组湿疹发生率第2个月为51.02%、第4个月51.02%、第6个月40.82%,两组比较有统计学差异(P<0.05)。结论 口服益生菌早期干预婴儿湿疹有效,发生率降低且病情程度减轻,为湿疹防治提供了新思路。Objective To investigate the early intervention effect of probiotics on infant eczema. Methods Ninety-sev- en artificial feeding children with eczema were randomly divided into two groups. The intervention group （n = 48） was given probiotics capsules orally for six months, when the eczema had exudation, 0.1% hydro- chloric acid Xiaochaihu solution were wet-packed. Those eczema without exudation, butyrate hydrocortison butyrate cream were used 2 times a day ,if the lesion with infection, use antibiotic ointment externally, in some severe cases, the loratadine syrup were used ; To the control group （ n = 49）, except the probiotics, the other method were the same. Observe the recurrence and severity of the eczema monthly in the clinic, by tel- ephone or site visits for six months. Results probability of Eczema attack of the intervention group in the first two months was 31.25%, 4 months was 27.08%, 6 months was 20.83%, and the severity gradually reduced. In the control group, probability of Eczema attack in 2 month was 51.02%, 4 month was 46.94% , 6 month was 40.82%, the relapse rate and severity of eczema were significantly lower in the in- tervention group（ P 〈 0.05 ） . Conclusion Early intervention with probiotics can reduce the attack and se- verity of eczema, provides a new idea for eczema prevention

关 键 词：益生菌 婴儿湿疹 早期干预 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]