药物对心肌缺血及其再灌注损伤离子通道的影响  

Influence of drugs on ion channels after myocardial ischemia and reperfusion injury

作　　者：李娟莉[1,2] 苏式兵[1] 

机构地区：[1]上海中医药大学复杂系统研究中心,上海201203 [2]上海中医药大学基础医学院生理教研室,上海201203

出　　处：《中国新药杂志》2012年第22期2642-2646,共5页Chinese Journal of New Drugs

基　　金：上海市教育委员会重点学科建设项目资助(J50301);上海市教委E-研究院中医内科建设计划资助项目(E03008)

摘　　要：综述近年来药物影响急性心肌缺血及I/R时离子通道的研究进展,为进一步研发新的防治缺血性心脏病及心律失常的有效药物提供参考。方法依据最新国内外文献,进行归纳总结。心肌膜上离子通道的异常变化与急性心肌缺血及再灌注损伤(I/R)时发生恶性心律失常密切相关,调节离子通道的异常变化,纠正心律失常是治疗心肌缺血及I/R的重要目的之一。We summarized recent studies about the influence of drugs on ion channels after acute myocardial ischemia and ischemia-reperfusion （I/R） based on the latest literature. This review will provide a reference for further research of new drugs that can prevent and treat ischemic heart disease and arrhythmia. Abnormal changes in myocardial membrane ion channels are closely related to malignant ventricular arrhythmias caused by acute myo- cardial ischemia and I/R. Regulation of the abnormal ion channels and prevention of the malignant ventricular arrhythmias are one important aspect in the treatment of myocardial ischemia and I/R.

关 键 词：药物 心肌缺血 缺血再灌注损伤 离子通道 

分 类 号：R969[医药卫生—药理学] R972.2[医药卫生—药学]