急性冠状动脉综合征患者血清Fgl2水平升高的临床意义  

Clinical significance of increased serum Fgl2 level in acute coronary syndrome

作　　者：郑振中[1] 詹俊峰[1] 章杨龙[1] 王梦洪[1] 郑泽琪[1] 彭景添[1] 魏云锋[1] 

机构地区：[1]南昌大学第一附属医院心血管内科,江西南昌330006

出　　处：《中国急救医学》2012年第11期980-984,共5页Chinese Journal of Critical Care Medicine

基　　金：国家自然科学基金项目（30960119）;江西省卫生厅科研项目（20081998）

摘　　要：目的检测急性冠状动脉综合征（ACS）患者外周血清中纤维介素（Fgl2）的水平，分析它与ACS及冠状动脉狭窄程度的相关性，探讨Fgl2在ACS中的临床价值。方法选择冠心病患者46例，其中急性心肌梗死患者（AMI组）12例、不稳定型心绞痛患者（UAP组）19例、稳定型心绞痛患者（SAP组）15例和非冠心病者（NCHD组）16例。冠心病患者根据冠状动脉造影结果，按冠状动脉病变支数分为三支病变组、双支病变组与单支病变组。酶联免疫吸附法（ELISA）测定各组血清Fgl2水平，比较各组血清Fgl2水平变化。按照Gensini评分评价冠心病患者冠状动脉狭窄程度，并评价血清Fgl2水平与冠状动脉狭窄程度的相关性。结果ACS组Fgl2水平明显高于SAP组和NCHD组（P〈0．05），SAP组与NCHD组比较差异无统计学意义（P〉0．05）。不同病变支数组之间比较差异无统计学意义（P〉0．05）。Gensini评分显示，AMI组与UAP组、SAP组之间比较差异无统计学意义（P〉0．05）。结论ACS患者急性期血清Fgl2水平明显增加，可能是冠心病特别是ACS冠状动脉微血栓形成有预测价值的急性时相性蛋白之一。冠心病患者冠状动脉狭窄程度与血清Fgl2水平无明显相关性。Objective To detect the peripheral serum levels of Fgl2 in the patients with acute coronary syndrome （ACS）, and to analyze its relationship with the ACS and the severity of coronary artery lesions. Methods Forty - six patients with coronary heart disease and 16 persons without coronary heart disease were studied. Among the patients with coronary heart disease, there were 12 patients with acute myocardial infarction（AMI）, 19 patients with unstable angina pectoris （UAP）, 15 patients with stable angina pectoris （SAP）. All the patients with coronary heart disease inspected by coronary angiography were divided into three vessel lesions group, two vessel lesions group and single vessel lesion group according to the lesions severity of coronary artery. The serum concentrations of soluble Fgl2 were measured in all the patients with coronary heart disease and controls. The extent of coronary arteriostenosis was evaluated with Gensini scores. The relationship of serum Fgl2 levels with the extent of coronary arteriostenosis were analyzed. Results Serum Fgl2 levels were remarkably higher in AMI group and UAP group than in SAP and the persons without coronary heart disease group （P 〈 0.05）, and there was no significant difference in the level of Fgl2 between SAP group and the persons without coronary heart disease group （P 〉 0. 05 ）. Gensini scores had no significant difference in patients with different types of coronary heart disease （P 〉 0.05）. Conclusion Level of serum Fgl2 increased in patients with ACS and it may be one of coronary microthrombosis acute - phase proteins and has predictive value in coronary heart especially in acute coronary syndromes. Levels of serum Fgl2 had no relationship with the extent of coronary arteriostenosis among the patients with Coronary heart disease.

关 键 词：急性冠状动脉综合征(ACS) 纤维介素(Fgl2) 

分 类 号：R543.3[医药卫生—心血管疾病]