大蒜提取物对小鼠免疫调节作用的实验研究  

Effects of Allium sativum Extract on Immunity Function in Mice

作　　者：方欢[1] 夏道宗[1] 潘东曼[1] 孙瑶婷[1] 吕晓文[1] 

机构地区：[1]浙江中医药大学药学院,杭州310053

出　　处：《中国食物与营养》2012年第11期70-71,共2页Food and Nutrition in China

基　　金：浙江省自然科学基金(项目编号:Y2110031);浙江省教育厅科研项目(项目编号:Y201016348);浙江中医药大学学生发展性资助项目(项目编号:2012018-2012023)

摘　　要：目的:研究大蒜提取物(Allium sativum extract,ASE)对正常小鼠免疫功能的影响。方法:将40只清洁级昆明种小鼠随机分为空白对照组[0.1mL蒸馏水/(10g.bw)]、大蒜提取物高剂量组[900 mg/(kg.bw)]、大蒜提取物中剂量组[600 mg/(kg.bw)]、大蒜提取物低剂量组[300 mg/(kg.bw)],每组10只,各组每天灌胃1次,连续给药14 d。观察大蒜提取物对正常小鼠免疫器官重量、巨噬细胞吞噬功能等的影响。结果:大蒜提取物能增强正常小鼠巨噬细胞吞噬功能(P<0.05),对免疫器官指数也有增加作用(P<0.05)。结论:大蒜提取物能增强正常小鼠的免疫功能。[Objective] To investigate the effects of AUium sativum extract （ASE） on immunity function in mice. [Method] Healthy KM mice were randomly divided into 4 groups including blank group [ 0. 1 mL distilled water /10 （ g · bw ） ], ASE high dosage group [900 mg/（kg ~ bw）], ASE middle dosage group [600 mg/（kg · bw）] and ASE low dosage group [300 mg/ （kg · bw] . Each group of 10 were intragastrically administered continuously once every day for 14d. [Result] ASE could the phagocytic function of macrophages in nor- mal mice （P 〈0. 05 ） and the weight of immune organs had improved. [Conclusion] ASE can enhance the immunity function of normal mice.

关 键 词：大蒜提取物 免疫调节 碳廓清实验 吞噬指数 

分 类 号：R285.5[医药卫生—中药学]