吸入糖皮质激素及联用长效β_2受体激动剂在儿童哮喘中的应用  

Inhaled Glucocorticoids and Combined with Long Acting β_2 Agonists in Children Asthma

作　　者：苏志强[1] 卓志强[1] 柯丹红[1] 

机构地区：[1]福建省泉州市儿童医院,362000

出　　处：《医学理论与实践》2012年第22期2746-2748,共3页The Journal of Medical Theory and Practice

摘　　要：目的:观察四种方法治疗儿童哮喘的疗效。方法:符合入选条件的哮喘患儿随机分为四组。A组42例:吸入沙美特罗替卡松干粉剂,每日早、晚各1吸;B组45例:吸入布地耐德干粉吸入剂,每日早、晚各2吸并联用福莫特罗干粉吸入剂,每日早、晚各1吸;C组48例:应用布地耐德干粉吸入剂,每日早、晚各1吸;D组43例:应用丙酸氟替卡松气雾剂,每日早、晚各1喷借助筒式吸舒吸入。吸入时间均为24周。观察晨间最大呼气峰流速占预计值的百分数为主要疗效指标。结果:治疗后第1周及第4周与治疗前相比,吸入治疗无论单用糖皮质激素或糖皮质激素联用长效β2受体激动剂均有差异性(P<0.05)。治疗后第8周、第12周及第24周与第4周相比差异无显著性。而4组间的比较差异无显著性。而使用短效β2受体激动剂方面4组患儿组间及用药前后均无差异。结论:大部分儿童哮喘患儿可以单用吸入糖皮质激素就能达到治疗效果。如果病情较重或病程较长者治疗初期可以先试用联合制剂,待病情稳定后改为吸入糖皮质激素。Objective： Observation of four methods for treatment in children with astima. Methods： According to the selected conditions in children with asthma were randomly divided into four groups. 42 cases of A group inhaled fluticasone propionate dry powder：Shah Mette Lo, a day early,late 1 suction; 45 cases in B group：inhalation of budesonide dry powder inhaler,a day early, late 2 suction parallel with Formoterol dry powder inhaler,a day early, late 1 suction; 48 cases in group C： application of budesonide dry powder inhaler, a day early, late 1 smoke inhalation; 43 cases in group D：application of fluticasone propionate aerosol, daily early, late 1 spray with cylinder type suction Shu inhalation. Suction time is 24 weeks. Observation of morning peak expiratory flow rate % in predicted percentage as the primary efficacy index. Results： After treatment of first weeks and 4 weeks compared with before treatment, inhalation in the treatment of both single with glucocorticoids or glucoeorticoid combined with long-acting β2 receptor agonists have difference （P〈0. 05）. After treatment for 8 weeks, 12 weeks and 24 weeks and 4 weeks there was no significant difference in. While the 4 groups had no significant difference in comparison. While the use of short-acting β2 agonist aspects in 4 groups before and after treatment between groups and there were no differences. Conclusion： Most of children asthma with inhaled cortieosteroids can only can achieve the therapeutic effect. If the disease is heavy or long term treatment early can first try to combine preparation, to be in stable condition after the change to inhaled cortieosteroids.

关 键 词：吸入糖皮质激素 长效Β2受体激动剂 儿童哮喘 

分 类 号：R725.6[医药卫生—儿科]