具有对称结构的新型双哌啶衍生物的合成  

Synthesis of Novel Bispidine Derivatives with Symmetrical Structure

作　　者：魏娇娇[1] 张月成[1] 赵继全[1] 

机构地区：[1]河北工业大学化工学院,天津300130

出　　处：《合成化学》2012年第6期693-695,700,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金(青年)资助项目(20806020)

摘　　要：以苄基哌啶酮和苄胺为起始原料,经双Mannich反应、黄鸣龙还原和Pd/C脱苄基合成了双哌啶(4)。以无水碳酸钾为缚酸剂,丙酮为溶剂,4分别与氯乙酸乙酯、氯乙腈反应制得新型的双哌啶衍生物5和7;5经皂化反应水解为新的双哌啶衍生物(6),其结构经UV-Vis,1H NMR和FT-IR表征。Bispidine（4） was synthesized from N-benzyl-4-piperidinone and benzyl amine by a three-step reaction of double Mannich,Wolff-Kishner,Pd/C catalyzed hydrogenation.Using postassium carbonate as the deacid agent and acetone as the solvent,two new bispidine derivatives（5 and 7） were synthesized by the reaction of 4 with ethyl chloroacetate and chloroacetonitrile,respectivily.Bispidine derivatives 6 was obtained by the saponification of 5.The structures were characterized by UV-Vis,1H NMR and FT-IR.

关 键 词：双哌啶 氯乙酸乙酯 氯乙腈 皂化反应 合成 

分 类 号：O626.3[理学—有机化学]