新型1-对三氟甲基苯基-β-咔啉-3-羰基双酰肼的合成及其抗菌活性  

Synthesis and Antibacterial Activities of Novel 1-Trifluoromethyl-phenyl-β-carboline-3-carbonyl-diacylhydrazine

作　　者：蔡瑛[1] 黄剑锋[1] 张美丹[1] 曾勇[2] 张耀谋[1] 

机构地区：[1]华南农业大学理学院,广东广州510642 [2]华南农业大学资源环境学院,广东广州510642

出　　处：《合成化学》2012年第6期736-739,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以L-色氨酸和对三氟甲基苯甲醛为原料,经Pictet-Spengler环合、酯化、氧化、肼解、酰化五步反应合成了四个新型的1-对三氟甲基苯基-β-咔啉-3-羰基双酰肼(5a～5d),其结构经1H NMR,IR,MS和元素分析表征。初步的抗菌活性测试结果表明,5b～5d对水稻纹枯菌有一定的抗菌活性。Four novel 1-trifluoromethyl-phenyl-β-carboline-3-carbonyl-diacylhydrazine（5a～5d） were synthesized from L-tryptophan and trifluoromethyl-benzaldehyde by a five-step reactions of Pictet-Spengler condensation,esterification,oxidation,N-alkylation and acylation.The structures were characterized by 1H NMR,IR,MS and elemental analysis.The preliminary antibacterial tests showed that 5b～5d exhibited certain antifungal activities against Rhizoctonia solani.

关 键 词：L-色氨酸 双酰肼 合成 抗菌活性 

分 类 号：O623.75[理学—有机化学] O625.63[理学—化学]