硝苯地平胶浆剂与片剂对术前紧张性高血压的作用对比  

Comparison of Nifedipine Mucilage and Tablets in Treating Preoperative Tension-type Hypertension

作　　者：刘加升[1] 刘斌[2] 马元华[1] 许正国[1] 

机构地区：[1]江苏省沛县中医院外科,江苏徐州221600 [2]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《中国药物评价》2012年第3期211-212,共2页Chinese Journal of Drug Evaluation

基　　金：江苏省徐州市医学科研课题(XWJ2011086);江苏省徐州市科技计划项目(XM12B068)

摘　　要：目的:比较硝苯地平胶浆剂与片剂对术前紧张性高血压的快速控制效果。方法:将120例术前紧张性高血压患者随机分为硝苯地平胶浆剂组(硝苯地平胶浆10mL,肛门内5cm处直肠灌注)和硝苯地平片剂组(硝苯地平片剂10mg,舌下给药),每组60例,观察对比两组用药20min后的降压效果。结果:两组患者术前在性别、年龄、体重、身高、入院时血压、术前液体入量等无显著差异(P>0.05)。硝苯地平胶浆剂组降压效果优于硝苯地平片剂组,有效率分别为96.7%和43.3%(P<0.001)。结论:硝苯地平胶浆剂直肠给药控制术前紧张性高血压效果满意,优于硝苯地平片剂舌下给药。Objective： To compare the rapid control effects of nifedipine mucilage and nifedipine tablets in treating preoperative tension-type hypertension. Methods： 120 patients suffering from preoperative tension-type hypertension were randomly divided into 2 groups： 60 cases in nmcilage group （ 10 mL by rectal administration） and 60 cases in tablet group （ 10 mg by sublingual adminis- tration）, and the rapid control effects were observed after 20 minutes. Results： There were no significant differences in gender, age, weight, height：, blood pressure on admission and preoperative intake volume between the two groups （P 〉 0. 05）. The antihy- pertensive effects in the mucilage group （ with an effective rate of 96.7% ） was better than that of the tablet group （43.3%）, P 〈 0. 001. Conclusion： The efficacy of nifedipine mucilage by rectal administration in treating preoperative tension-type hypertension is superior to that of nifedipine tablets by sublingual administration.

关 键 词：硝苯地平胶浆剂 术前紧张性高血压 抗高血压药 

分 类 号：R619[医药卫生—外科学]