血清胱抑素C在糖尿病及高血压早期肾损害中的临床意义  

The clinical significance of serum Cystatin C the diagnosis of early renal function injury for diabetes meiiitus and hypertention

作　　者：徐明伟 徐建东 吴善玲 

机构地区：[1]甘肃省第二人民医院体检中心,甘肃兰州730000

出　　处：《甘肃医药》2012年第11期821-823,共3页Gansu Medical Journal

摘　　要：目的:探讨血清CysC含量对高血压、糖尿病患者早期肾损害临床诊断的意义。方法:收集尿常规定性阴性的61例糖尿病患者,46例高血压患者以及80例健康体检者的血清进行CysC、BUN、Cr测定,采用免疫比浊法进行CysC,采用酶法检测传统的肾功能标志物血清BUN、Cr。结果:糖尿病、高血压组患者CysC水平明显高于正常对照组,血清CysC阳性检出率高于血清BUN、Cr,分别是38.3%、3.7%、5.6%。结论:血清CysC是一种比血清肌酐、尿素氮更能更好反映肾功能的指标,测定其含量可作为早期肾损伤诊断指标。Objective：To evaluate the clinical significance of serum cysta tin C as a early diagnosis test for the patients with early renal function injury caused by diabetesmellitus and hyperteusion. Methods： CysC were detected with immune turbidimetry traditional renal function marker of serum creatinine and urea nitrogen levels were detected with enzym icmethod. Results： CysC level in DM and hypertension group were significantiy higher thon that of nomal control group,The positive of CysC、Urea、Cr in patients DM and hypertension group was 38.3% 、3.7% 、5.6% respectively. Conclusion： Serum cystatin C is more sensitive and specific than urea and creatinine to evaluate the glonerular filtration rate. It could be used to as sensitive indicator for diagnose the damage in kidney of diabetic.

关 键 词：胱抑素C 高血压 糖尿病 肾功损害 

分 类 号：R692[医药卫生—泌尿科学]