抑郁症患者静息态脑活动与焦虑症状的相关性  

Relationship between regional homogeneity of depressed patients and anxious symptoms： a resting-state fnRI study

作　　者：阎锐[1] 姚志剑 韩莉[1] 汤浩[1] 罗国平[3] 卢青[3] 

机构地区：[1]南京医科大学附属脑科医院,南京210029 [2]南京神经精神病学研究所 [3]东南大学学习科学研究中心

出　　处：《中华行为医学与脑科学杂志》2012年第11期988-990,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81071135,30900356）,南京市科技发展项目（ZKX09037,201104010）

摘　　要：目的探讨中青年抑郁症患者静息态脑区自发性活动特征与不同焦虑程度的相关性。方法10例汉密尔顿抑郁量表焦虑／躯体化因子分≤1分的轻度焦虑／躯体化因子抑郁患者，10例焦虑／躯体化因子分≥2分的中重度焦虑／躯体化因子抑郁患者，及10例健康对照进行3．0T静息态功能磁共振扫描。将差异有显著的脑区局部一致性（regionalhomogeneity，ReHo）值与汉密尔顿量表总分和焦虑／躯体化因子做简单线性相关分析。结果3组ReHo值在左小脑脚（-39，-77，-29；K=15）、左角回（-56，-63，22；K：13）和左前扣带回（-3，22，29；K=19）的差异均有统计学意义（P〈0．05，Alphasim矫正）；轻度组较健康对照左前扣带回ReHo值增高，左小脑脚ReHo值降低；中重度焦虑组较正常对照左角回、左前扣带回ReHo值增高，左小脑脚ReHo值降低；两组患者之间差异无统计学意义。轻度组左前扣带回与精神性焦虑正相关r=0．646，P=0．043），中重度组左前扣带回与躯体性焦虑呈正相关r=0．693，P=0．038）。结论抑郁症患者自身存在基础状态下脑区局部神经元活动的异常，其严重程度与临床焦虑／躯体化症状有关。Objective To investigate the differences of regional homogeneity（ReHo） in depressed patients with vary degrees of anxiety using resting-state function MRI, and the relationship vary degrees of anxiety symp- toms. Methods 10 depressed patients with scores less than I in anxiety/somatization factor of Hamilton depres- sion scale, 10 depressed patients with scores above 2, and 10 age-, gender-, education-matched healthy controls were underwent resting-state fMRI scanning at 3.0 Tesla. Correlation analysis between ReHo with significant differences level of brain region and the total score of Hamilton depression scale, and anxiety/somatization factor were underwent respectively. Results The brain regions with significant difference level among three grou^s were the left posterior cerebellum （ - 39, - 77, - 29 ; K = 15 ）, the left angular gyrus （ - 56, - 63,22 ; K = 13 ） and the left anterior cingulate （ - 3,22,29 ; K = 19） （P 〈 0.05, Alphasim） ; compared with healthy group, the mild anxiety group showed significantly decreased ReHo in the left posterior cerebellum, and increased ReHo in the left anterior cingulate ; the moderate and severe anxiety group showed significantly decreased ReHo in the left posterior cerebel- lum, and increased ReHo in the left anterior cingulate and the left angular gyms; no significant differences were found in patient groups. In the mild anxiety group, the left anterior cingulate positively correlated with the anxiety severity （r = 0. 646, P = 0. 043 ）, and in the severe anxiety group positively correlated with the somatic anxiety （r = 0. 693, P = 0. 038）. Conclusion Depressed patients showed abnormal neural activity in resting state, and the de- gree of abnormality is associated with clinical anxiety/somatization symptoms.

关 键 词：抑郁症 焦虑 躯体化因子 静息态 功能磁共振 局部一致性 

分 类 号：R445.2[医药卫生—影像医学与核医学]