健康青年人猎奇性人格与脑白质各向异性分数值相关性  

Correlation between novelty seeking personality of healthy young individuals and fractional anisotropy val- ue of white matter

作　　者：刘冲[1] 李卉[1] 张建军[1] 王莉[1] 王淑梅[1] 张云亭[2] 于春水[2] 

机构地区：[1]保定市第一中心医院CT/MRI室,保定071000 [2]天津医科大学总医院放射科

出　　处：《中华行为医学与脑科学杂志》2012年第11期1035-1037,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的应用基于体素分析的扩散张量成像研究健康青年人猎奇性人格与脑各向异性分数之间的相关性，以研究人格的脑白质微观结构基础。方法333名右利手受试填写三维人格问卷及贝克抑郁问卷，并行三维T1结构像及扩散张量成像扫描。所有扩散张量成像数据行预处理后，使用统计参数图（SPM）8软件，以年龄和抑郁评分为控制变量，对整体数据进行偏相关分析，研究脑各向异性分数值与猎奇性人格评分的相关性（以簇体积大于30个体素，且P〈0．001（未矫正）为差异有统计学意义的阈值）。结果男性和女性猎奇性评分分别为（14．554-4．66）分和（14．08±5．42）分，两组差异无统计学意义（t=0．81，P=0．46）。男性的Beck抑郁评分较女性高（t=3．10，P=0．002），分别为（9．23±7．90）分和（6．76±5．79）分。基于体素的全脑分析发现猎奇性评分与右侧额下回、右侧缘上回各向异性分数值负相关（P〈0．001）。结论猎奇性人格有特定的脑白质微观结构基础。Objective To study the correlation between novelty seeking（NS） personality of healthy young individuals and fractional anisotropy （FA） with voxel-based analysis （VBA） of diffusion tensor imaging （DTI） , and explore the mierostrueture of white matter of personality. Methods Total 333 healthy right handed volunteers completed the Chinese version of the TPQ and the Beck Depression Inventory（BDI）, and then finished 3D T1 structure scan, DTI scan. All preproeessed DTI datum was analyzed with SPM8 soft ware in partial correlation anal- ysis, using age and depression scores as controlled variable. The correlation studied between NS and FA （ a voxel significance threshold P 〈 0. 001 and a cluster extent threshold of 30 voxels ）. Results NS score of men and women were 14.55 ± 4.66 and 14.08 ±5.42 points, and the difference between the two groups was not statistically significant （ t = 0.81, P = 0.46）. BDI score of men were higher than that of women （ t = 3.10, P= 0.002） , which were 9.23 ±7.90 and 6.76 ±5.79 points respectively. NS correlated negatively with FA of the right inferior fron- tal gyrus, and the right supramarginal gyrus（P 〈 0.001 ）. Conclusion NS personality has specific microstructure background of white matter.

关 键 词：人格 扩散张量成像 基于体素分析 猎奇性 

分 类 号：R445.2[医药卫生—影像医学与核医学]