黄芩苷温敏凝胶的处方筛选及体外释放研究  

Preparation optimization and in vitro release of baicalin thermosensitive gel

作　　者：朱铁梁[1,2] 胡霞[3] 张莉[1,2] 陈孝储[1,2] 郭一沙[1,2] 陈莉[1,2] 张岭[1,2] 

机构地区：[1]武警后勤学院药剂学教研室,天津300162 [2]武警后勤学院附属医院药剂科,天津300162 [3]武警湖北总队医院药剂科,湖北武汉430060

出　　处：《中草药》2012年第11期2164-2167,共4页Chinese Traditional and Herbal Drugs

基　　金：武警医学院面上项目(WY-2008-17)

摘　　要：目的制备黄芩苷温敏凝胶并考察其体外释放特征。方法以黄芩苷为主药,泊洛沙姆407和泊洛沙姆188为凝胶材料,甲基纤维素为黏度调节剂,制备黄芩苷温敏凝胶;考察黄芩苷用量、凝胶材料比例以及黏度调节剂对胶凝温度的影响;采用UV法考察其体外释放规律。结果所制黄芩苷温敏凝胶胶凝温度为35.3℃。体外释放结果显示黄芩苷温敏凝胶在120min累积释放率为78.06%。结论将黄芩苷制成温敏凝胶能加快药物的溶出速率,通过调整黄芩苷用量、温敏凝胶材料比例以及黏度调节剂可制得性状优良的温敏凝胶剂。Objective TO prepare the thermosensitive in situ gel of baicalin and investigate the in vitro drug release behavior of baicalin. Methods The thermosensitive in situ gel was prepared with baicalin as main component, Poloxamer 407 and Poloxamer 188 as the gel matrixes, together with methyl cellulose as thickening agent. The effects of baicalin dosages, gel matrix ratios, and viscosity regulator on gelatinization temperature were investigated and the in vitro drug release was determined by UV. Results The gelatination temperature for thermosensitive in situ gel ofbaicalin was 35.3 ℃. The in vitro accumulate release ratio ofbaicalin in the thermosensitive gels was 78.06% after 120 min. Conclusion The preparation of baicalin into thermosensitive in situ gel could accelerate drug dissolution rate. Thermosensitive gel of baicalin with qualified characteristics could be preparaed through regulating the baicalin dosage, gel matrix ratios, and viscosity regulator.

关 键 词：黄芩苷 温敏凝胶 UV法 胶凝温度 体外释放率 

分 类 号：R283.6[医药卫生—中药学]