花旗泽仁对胰岛素抵抗大鼠脂肪因子的影响Ⅱ  

Influence of HQZR on the Adipocytokines in Insulin Resistance Rats

作　　者：葛鹏玲[1] 韩东卫[1] 李冀[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2012年第5期32-33,共2页Acta Chinese Medicine and Pharmacology

基　　金：国家科技重大专项重大新药创制项目(2012ZX09103201-018);黑龙江省自然科学基金(LC2011C03);黑龙江省教育厅项目(11521265);黑龙江省教育厅留学回国人员科技项目择优资助项目(2010年);2009黑龙江省博士后科学基金(LBH-Z09001);黑龙江中医药大学校基金(200723)

摘　　要：目的:观察花旗泽仁对2型糖尿病胰岛素抵抗(Insulin Resistance,IR)大鼠血清瘦素(Leptin)和肿瘤坏死因子-a(TNF-a)的影响,探索花旗泽仁改善胰岛素抵抗的作用机制。方法:应用复合脂肪乳灌胃加链脲佐菌素腹腔注射的方法复制2型糖尿病胰岛素抵抗大鼠模型;采用放射性免疫分析法检测肿瘤坏死因子-α(TNF-α)和瘦素(Leptin)水平。结果:花旗泽仁明显降低了血清TNF-α和Leptin水平,差异显著(P<0.01,P<0.05)。结论:花旗泽仁可通过调节血清TNF-α和Leptin水平而改善2型糖尿病胰岛素抵抗状态。Objective ： To observe the influence of JZY on the level of TNF - a and APN in insulin resistance （IR） rats and to discuss the mechanism of JZY in ameliorating insulin resistance and metabolism syndrome. Method：Set up the IR model in rats by feeding them high fat diet combining injecting small dose of STZ once to them. 2. Use different doses of JZY to treat the IR rats compared with rosiglitazone. 3. Observe the differences within each group on the side of insulin sensitivity and the level of TNF-α and APN. Result：Compared with blank group, remarkably TNF -α ascended and APN fell in model group and Compared with model group, TNF - α fell and APN ascended, which had a significant difference（P 〈001 ,P 〈0.05 ）in JZY group. Conclusion ：JZY can ameliorate IR by regulating the level of TNF-α and APN in serum in IR rats.

关 键 词：胰岛素抵抗 花旗泽仁 血清瘦素(Leptin) 肿瘤坏死因子-a(TNF-a) 

分 类 号：R285.5[医药卫生—中药学]