黄芩、黄连和黄柏分别干预热病证候的代谢组学层面差异分析  

Comparative Analysis of Radix Scutellariae,Cortex Phellodendri and Coptis Chinensis Franch Intervention Fever Syndrome Based on Metabonomics Technology

作　　者：王海平[1] 刘树民[1] 柳长凤[1] 陈平平[1] 冯倩晴[1] 

机构地区：[1]黑龙江中医药大学中医药研究院,黑龙江哈尔滨150040

出　　处：《中医药学报》2012年第5期80-84,共5页Acta Chinese Medicine and Pharmacology

基　　金：国家重点基础研究发展计划973计划(2007CB512608);哈尔滨市科技创新人才研究专项资金项目(2008RFXXS042)

摘　　要：目的:比较分析黄芩、黄连和黄柏干预热病证候的异同。方法:运用代谢组学技术,以2,4-二硝基苯酚复制的热病证候模型为载体,分别利用黄芩、黄连和黄柏对热病证候进行干预。结果:以热病证候的整体代谢和内源性生物标志物的变化为评价指标,黄芩、黄连和黄柏对表达上调(下调)的热病证候生物标志物的干预数量分别为30,28,21(14,6,3)个。结论:从干预热病证候生物标志物数量得出,黄芩干预作用最佳,黄连次之,黄柏最弱;从干预热病证候生物标志物种类上看,三药的干预作用各有异同。Objective ： To make a comparative analysis of rhizoma coptidis, radix scutellariae, cortex phellodendri interven- tion with fever syndrome of similarities and differences. Methods ： With the metabonomics technology, the fever syndrome models were interfered by radix scutellariae, cortex phellodendri and coptis chinensis franch, coping the fever syndrome models as the carrier. Results： With the overall metabolic syndrome, fever and endogenous biological markers for the change of the evaluation index, Radix scutellariae, Coptis chinensis franch, Cortex phellodendri over -active （cut） of the fever syndrome of biological markers were 30,28,21 intervention number （14,6,3）. Conclusion： From intervention fe- ver syndrome biological markers number, radix scutellariae intervention has the best effect;coptis chinensis franch takes the second place and cortex phellodendri is the end; From intervention fever syndrome type biological markers,the inter- vention roles of the three drugs have their own similarities and differences.

关 键 词：代谢组学 生物标志物 黄芩 黄连 黄柏 

分 类 号：R284.1[医药卫生—中药学] R285.5[医药卫生—中医学]