天麻钩藤饮口服缓释片中天麻素及松脂醇二葡萄糖苷同步缓释性考察  

Investigation of Synchronous Release of Gastrodin and Turpentine Alcohot-biglucosid from Tianma Gouteng Decoction Oral Sustained Release Tablet

作　　者：刘文[1] 司娜[1] 杨颂[1] 王群[1] 陈龙富[1] 

机构地区：[1]贵阳中医学院,贵阳550002

出　　处：《中国实验方剂学杂志》2012年第23期46-48,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究天麻钩藤饮口服缓释片中天麻素和松脂醇二葡萄糖苷的同步缓释性,为天麻钩藤饮的剂型改革提供实验依据。方法:采用转篮法进行体外溶出度的考察,HPLC测定天麻素及松脂醇二葡萄糖苷的含量,计算药效成分累积释药率,采用相似因子进行释放曲线相似性比较。结果:天麻钩藤饮口服缓释片中天麻素和松脂醇二葡萄糖苷在体外可持续释放12 h,且具有同步性。结论:天麻钩藤饮缓释片具有同步缓释的溶出特点,天麻素和松脂醇二葡萄糖苷的释放具有相似性。Objective： To study on synchronous release of gastrodin and turpentine alcohot-biglucosid from Tianma Gouteng decoction sustained release tablet, and provide experimental basis for formulation reform of Tianma Gouteng decoction. Method： In vitro dissolution was investigated by rotating basket method, the content of gastrodin and turpentine alcohot-biglucosid were determined by HPLC, similar factor was adopted for comparing similarity of drug release curve by calculating cumulative dissolution ratio of medicinal components. Result： Gastrodin and turpentine alcohot-biglucosid could suatained relese 12 h in vitro, and had synchronization. Conclusion ： Tianma Gouteng decoction sustained release tablet had dissolution characteristics of sustained release, release of gastrodin and turpentine alcohot-biglucosid had similarity.

关 键 词：天麻钩藤饮 缓释片 天麻素 松脂醇二葡萄糖苷 同步释放 

分 类 号：R283.6[医药卫生—中药学]