不同隔姜灸治时间对慢性浅表性胃炎脾胃虚寒证患者血清中SOD和MDA的影响  

Influence of Serum SOD and MDA by Moxibustion on Ginger Therapy for Chronic Superficial Gastritis Spleen-Stomach Vacuity Cold Patients with Differents Time

作　　者：易展[1] 刘密[1] 常小荣[1] 严洁[1] 谢华[1] 王德军 艾坤[3] 刘未艾[1] 

机构地区：[1]湖南中医药大学针灸推拿学院,长沙410007 [2]深圳市福田区中医院,广东深圳518000 [3]郴州市第一人民医院,湖南郴州423000

出　　处：《中国实验方剂学杂志》2012年第23期301-304,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金课题(30973802);湖南省中医药科研计划课题(2010101);长沙市科技计划重点项目(K1005020-31)

摘　　要：目的:探讨隔姜灸不同灸治时间对慢性浅表性胃炎脾胃虚寒证患者血清中超氧化物歧化酶(superoxide dismutase,SOD)与丙二醛(malondialdehyde,MDA)的影响。方法:将45例浅表性胃炎脾胃虚寒证患者随机分为隔姜灸20 min组(A组)15例、隔姜灸40 min组(B组)15例、雷尼替丁组(C组)15例。治疗组每天隔姜灸1次,10 d为1个疗程,疗程间休息1 d,共治疗2个疗程;对照组服用雷尼替丁每次0.15 g,1 d 2次,连续服药10 d为1个疗程,疗程间休息1 d,共服药2个疗程。于实验治疗前、治疗后分别抽血取血清检测SOD,MDA的含量,以此观察隔姜灸的疗效及对SOD和MDA的影响。结果:①3组的SOD含量:在各组治疗后与其治疗前比较均有显著性差异。B组治疗前后SOD含量的增加,与A,C两组比较均有显著性差异(P<0.05)。②3组的MDA含量:在各组治疗后与其治疗前比较均有显著性差异。但组间比较,各组治疗前后MDA含量没有显著性差异。结论:隔姜灸与雷尼替丁均能使血清中抗氧化酶SOD活性升高而自由基MDA水平降低,且隔姜灸40min提高SOD水平效果显著,明显高于隔姜灸20 min和雷尼替丁对SOD的作用。证明隔姜灸对浅表性胃炎脾胃虚寒证患者氧自由基产生与清除的酶系统具有良性调节作用,隔姜灸治疗浅表性胃炎脾胃虚寒证取效可能与此机制有关。Objective： To explore the content Changes of serum superoxide-dismutase （SOD） and malondialdehyde （MDA） of chronic superficial gastritis spleen-stomach vacuity cold （CSG-ssvc） patients by moxibustion on ginger therapy of differents moxibustion time. Method： Under the random, contrast and single- blind research method, 45 cases who conform to the standard of CSG-ssvc were randomly divided into three groups ： the therapy group A （Moxibustion on ginger to the acupoints with 20 minutes） with 15 cases, the therapy group B （moxibustion on ginger to the acupoints with 40 minutes） with 15 cases and the medicine group C （taking medicine of ranitidine） with 15 cases. Moxibustion on ginger to the patients of therapy groups 1 time per day, and the patients of medicine group took ranitidine 0.15 g, 2 times per day. Three groups were continuous insist on 10 days for 1 treatment course, took a rest for 1 day and took 2 courses by all. The contens of Anti-oxidation factors were taken by draw blood and test serum on the first day and the 23 rd day. Result： （1）All the three groups contents of SOD were significantly augmented after 2 treatment courses, there was a statistically difference when compared to the contents before treatments （P 〈 0.05）. And there was a statistically difference when compared to matched the changes of group B and group A, C （P 〈 0.05 ）. （2）All the three groups contents of MDA were significantly decreased after 2 （P 〈 0.05 ）, treatment courses, there was a statistically difference when compared to the contents before treatments but there was no statistically difference compared with three groups. Conclusion： It can increase the contents of SOD and decrease the contents of MDA with both Moxibustion on ginger therapy and taking ranitidine. Moxibustion on ginger therapy for 40 minutes can increase SOD contents significantly, and the results are obviously higer than Moxibustion on ginger therapy for 20 minutes group and taking ranitidine group. Confirm

关 键 词：隔姜灸 浅表性胃炎 脾胃虚寒证 超氧化物歧化酶 丙二醛 

分 类 号：R287[医药卫生—中药学]