血栓心脉宁胶囊对冠心病患者炎性因子的影响  

Influence of Xueshuan Xinmaining Capsule on Inflammatory Factors in Patients with Coronary Heart Disease

作　　者：任江华[1] 

机构地区：[1]河北省中医药研究院,石家庄050000

出　　处：《中国实验方剂学杂志》2012年第23期319-321,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨血栓心脉宁胶囊对冠心病患者的疗效及对白细胞介素-6(IL-6),肿瘤坏死因子(TNF-α)及高敏C反应蛋白(hs-CRP)的影响。方法:65例冠心病患者随机分为治疗组33例和对照组32例。两组均采用常规治疗,治疗组加用血栓心脉宁胶囊,4粒/次,3次/d。疗程8周。观察IL-6,TNF-α,hs-CRP水平及心电图和心绞痛发作次数。结果:治疗组心绞痛总有效率90.9%,优于对照组的56.3%(P<0.01);治疗组心电图总有效率84.8%,优于对照组的56.3%(P<0.01);治疗后治疗组血清IL-6,TNF-α及hs-CRP水平均明显低于对照组(P<0.01)。结论:血栓心脉宁胶囊能减少患者心绞痛发作次数,改善患者心电图,并能降低患者IL-6,TNF-α,hs-CRP水平,其作用机制可能与抗炎症反应有关。Objective ： To investigate coronary heart disease and impact on interleukin reactive protein （hs-CRP）. Method： Sixty-five treatment group of 33 cases and control group of treatment group was additionally given Xueshuan TNF-α, hs-CRP, ECG and the count of angina the influence of Xueshuan Xinmaining capsule in patients with （IL-6） , tumor necrosis factor （TNF-a） and high-sensitivity C- patients with coronary heart disease were randomly divided into 32 cases. Both groups were given a conventional treatment, the Xinmaining capsule, 4 grain tid for 8 weeks. The level of IL-6, pectoris were observed. Result： For angina pectoris, the total effective rate of treatment group was 90.9% , better than the control group of 56.3% （P 〈 0.01 ）. The electrocardiogram total effective rate in treatment group was 84.8% , better than the control group of 56.3% （P 〈 0.01 ）. After treatment, the serum IL-6,-TNF-α and hs-CRP in treatment group were significantly lower than those in the control group （P 〈 0.01 ）. Conclusion ： Xueshuan Xinmaining capsule can reduce the count angina pectoris in patients, improve patients＇ECG and reduce IL-6, TNF-α and hs-CRP level. Its mechanism may be related to its anti-inflammatory action.

关 键 词：冠心病 血栓心脉宁胶囊 白介素-6 肿瘤坏死因子-Α 高敏C反应蛋白 

分 类 号：R287[医药卫生—中药学]