hs—CRP与IL-6在新生儿败血症早期联合检测的临床意义  

Clinical significance of combined detection of hs--CRP and IL--6 in early diagnosis of neonatal sepsis

作　　者：杨晓荣 訾和平 

机构地区：[1]陕西省榆林市中医医院,榆林719000

出　　处：《按摩与康复医学》2012年第32期28-29,共2页Chinese Manipulation and Rehabilitation Medicine

摘　　要：目的：探讨超敏C-反应蛋白（hs—CRP）与白介素-6（IL-6）在新生儿败血症早期联合检测的临床意义。方法：选择60例败血症急性期新生儿、56例败血症恢复期新生儿为研究对象，同时选择40例健康新生儿为对照组。检测三组hs—CRP和IL-6的水平及二者联合检测对诊断新生儿败血症早期的临床价值。结果：败血症急性期新生儿血清hs—CRP和IL-6的水平显著高于败血症恢复期新生儿及对照组（P〈O．05）；hs—CRP和IL-6二者联合检测的敏感性、特异性、阳性预测值和阴性预测值妁优于单项检测。结论：hs—CRP和IL-6诊断新生儿败血症快速有效，二者联合检测可显著提高检出率。Objective： To explore the clinical significance of combined detection of high sensitive c--reactive protein （hs--CRP） and Interleukin-- 6 （IL--6） in early diagnosis of neonatal sepsis. Methods：Selected 60 cases of septic acute stage and 52 patients of septic restoration stage as research subjects. 40 healthy children were considered as control group. Serum hs--CRP and IL--6 level were compared among three groups and the evaluation of combined detection for early diagnosis of neonatal sepsis was explored. Result：Serum hs--CRP and IL--6 level in septic acute stage patients were much higher than that in septic restoration stage cases and control group （P〈0.05） ; The sensitivity, specificity, positive predictive value and nega- tive predictive value of hs--CRP and IL--6 combined detection were superior to than that of IL--6 or hs--CRP separately. Conclusion： Hs--CRP and IL--6 can be rapid diagnostic indexes for early diagnosis of neonatal sepsis. Combined detection of two markers can greatly increase detection rate.

关 键 词：败血症 新生儿 超敏C-反应蛋白 白介素-6 

分 类 号：R4[医药卫生—临床医学]