北京甲3流感流行中合并其它呼吸道病毒感染的调查  

Serological analysis and detection of multi-virus during the prevalence of FluA3 in Beijing

作　　者：段佩若[1] 赵华[1] 彭世勇 

机构地区：[1]北京解放军第二炮兵总医院医学实验科,北京100088

出　　处：《免疫学杂志》2000年第2期127-129,共3页Immunological Journal

基　　金：全军九.五医学卫生科研基金!资助项目 (95 A- 0 11)

摘　　要：目的为获得北京甲 3流感暴发中其它主要呼吸道病毒介入和血清学依据。方法应用系列呼吸道病毒桥联酶标试剂盒对 2 0 4例患者分泌物进行多病毒抗原检测 ;应用间接免疫荧光法对流行前人群 5 0例和流行后患者恢复期血清 41例 ,分别作呼吸道合胞病毒 (RSV) ;副流感病毒 3型 (PIV3)以及腺病毒 7型 (Adv7)的血清学检测。结果 2 0 4例标本中病毒总检出率为6 7.1% (137/2 0 4) ,其中甲型流感 (Flu A)总检出率为 5 7.3% (117/2 0 4) ,Flu A两种病毒以上混合感染率为 70 .9% (83/117) ,以RSV与 Flu A混合感染最高为 43.6 % ;Flu B和 PIV与 Flu A次之 ;Adv再次之。流行前后 RSV、PIV3和 Adv7血清比较 ,抗体均大幅度提高。结论北京 1998年 12月是以甲 3流感为主并存在其它病毒 RSV、PIV3和 Adv7的介入和混合协同感染。ObjectiveIn order to obtain information of other types of respiratory viruses infection and their serological data during the FulA3 prevalence in Beijing.Methods We detected multi virus antigens in 204 cases of specimens using series of diagnosis kits for respiratory viruses,and serologically analyzed 51 cases of serum samples before the prevalence and 41 cases in convalescence,including RSV,PIV3 and Adv7.Results The whole detection rate of viruses is 67.1%(137/204) in the 204 specimens.The whole detection rate of FulA is 57 3%(117/204)in it Mixed infection rates of Flu A and other viruses are 70.9%(83/117).Mixed infection of FulA and RSV is the highest(43 6%)among them,those of Flu A and FluB or PIV the second and that of FluA and Adv the lowest.Serological analysis of RSV,PIV3 and Adv7 shows that antibody levels of the 3 types of viruses are all increasing,after the prevalence.Conclusion Through the test of virus antigens and serological analysis , we think that the prevalence is a kind of mixed infection of FluA and RSV,PIV3,Adv7,et al,however FluA3 is the main virus. [

关 键 词：血清学 流行性感冒 呼吸道感染 并发症 

分 类 号：R511.7[医药卫生—内科学]