三七总皂甙对家兔脑损伤后脑组织中丙二醛含量变化的影响  

Effects of panax notoginseng saponins on malondialdehyde content of the brain following brain injury in rabbits

作　　者：韩金安[1] 匡永勤[2] 周虎田[2] 杨立斌[2] 曾凡俊[2] 孙增会 胡威夷[2] 王晓丽 

机构地区：[1]解放军477医院神经外科,湖北襄樊441003 [2]成都军区总医院神经外科,四川成都610083

出　　处：《中国病理生理杂志》2000年第3期269-271,共3页Chinese Journal of Pathophysiology

摘　　要：目的 :研究三七总皂甙 (PNS)对减轻颅脑创伤后脑组织损伤机制。方法 :改良八木国夫法检测家兔脑损伤后 2 4h脑组织中的丙二醛 (MDA)含量、脑组织含水量及脑组织超微结构改变 ,观察PNS对上述指标的影响。结果 :脑损伤后 2 4h脑损伤 +PNS组及对照组脑组织中MDA含量分别为 (81.43± 9.72 )nmol/g湿脑 ,(76 87± 8.31)nmol/g湿脑 ,明显低于脑损伤组MDA含量 (10 6 .5 2± 17.6 8)nmol/g湿脑 ,(P <0 .0 1) ;脑损伤 +PNS组及对照组脑组织中水含量分别为 78.97%± 0 .91% ,78.35 %± 0 .89% ,明显低于脑损伤组 80 .74± 0 .98(P <0 0 1)。损伤脑组织中MDA含量与伤后脑水肿程度呈正相关 (P <0 .0 1) ,同时脑损伤组出现明显的脑组织超微病理改变。结论 :PNS能够降低颅脑损伤后自由基的产生 ,减轻脑水肿和脑组织病理损害 ,对颅脑损伤具有一定的脑保护作用。AIM: To study the protective effect of panax notoginseng saponins (PNS) on brain in experimental brain injury. METHODS:A model of local cerebral injury on rabbits was set up by a drop of 100 weight at 20cm height hitting on the left epidura. PNS 100mg/kg was intravenous injection at 30min, 12 h after brain injury. The content of malondialdehyde (MDA) and water in brain tissue at 24h after brain injury were measured, and the changes of the ultrastructures of brain tissue was observed.RESULTS:The MDA in the brain tissue following brain injury significantly increased, which related to the degree of brain edema; PNS dramatically decreased MDA in the brain tissue following brain injury and can alleviate the neuron ultrastructures damage.CONCLUSION:The inhibition of injury induced MDA increasing in the brain tissue by PNS may contribute to its overall neuroprotective action.

关 键 词：丙二醛 颅脑损伤 三七总皂甙 家兔 

分 类 号：R651.150.2[医药卫生—外科学]