镉对雄性生育功能的影响  

Effects of cadmium on male reproduetive ability in rat

作　　者：杨建明[1] 陈琼宇[2] 曾祥斌[1] 许江琳 逄兵[1] 周袁芬[1] 金泰[1] 蒋学之[1] 

机构地区：[1]上海医科大学劳动卫生教研室,200032 [2]河南医科大学劳动卫生教研室

出　　处：《中国公共卫生》2000年第4期313-314,共2页Chinese Journal of Public Health

摘　　要：为研究镉对雄性生育功能的影响 ,将大鼠皮下注射氯化镉染毒 5周。雄鼠染毒结束后与正常成年雌鼠按 1∶2合笼交配 1周 ,于妊娠第 2 1天处死雌鼠 ,检查雌鼠的黄体数 ,胎鼠的性别、体重、身长和尾长。结果显示 ,随着染毒剂量的增高 ,各组参与交配的雄鼠数显著下降 (P <0 .0 5 ) ,交配成功的雌鼠数也显著降低 (P <0 .0 1)。低剂量组有活胎的孕鼠数明显低于对照组 (P >0 .0 5 ) ,中、高剂量组孕鼠无活胎。 2组胎鼠的平均体重、身长、尾长和胎鼠性别比例与对照组比较无显著差异(P >0 .0 5 )。 2组胎鼠未发现明显的骨路畸形。这表明镉可明显影响雄性生育功能 。To explore the effects of cadmium on male reproductive ability in rat, 24 adult rats were divided randomly into four groups respectively. 0,0.5,1,and 2 mgCd\+\{2+\}/kg body weight were injected subcutaneously in different groups, once a day, and five days per week. The exposure period is 5 weeks. The male rats finished cadmium exposure were matched with normal female rats in the ratio of 1:2.On the 21st day of the pregnancy, the female rats were sacrificed and the number of corpus luteum, the sex ratio, weight, body length, and tail length of fetuses were measmed. The results showed that with the increase of dose of cadmium, there was a decreased mated rate in male rats (P<0.05). Female rats mated successfully in cadmium exposed groups were significantly fewer than that in the control group (P<0.01). The number of female rats with living fetus in 0.5mgCd\+\{2+\}/kg group was smaller than that in the controls (P>0.05). There was no living fetus in 1 and 2mgCd\+\{2+\}/kg groups. Comparison of the body weight, body height, tail length, and gender of fetus between 0. 5 mgCd\+\{2+\}/kg and the control group showed no significant difference.No malformation in bone was found in the two groups. These findings revealed that cadmiuln can significantly affect male fenility, but has no offects on fetus when female rats are pregnant successfully.

关 键 词：镉 雄性生育力 胎鼠 生殖毒性 

分 类 号：R995[医药卫生—毒理学]