升清胶囊对胆汁促成核蛋白及生化指标影响的临床研究  

Clinical study on effects of Shengqing capsule on nucleoprotein α_1-acid glycoprotein and biochemical indicators of bile in patients with cholelithiasis

作　　者：杨吉勇[1] 张静喆[1] 

机构地区：[1]上海中医药大学附属龙华医院普外科,上海200032

出　　处：《肝胆胰外科杂志》2012年第6期459-462,共4页Journal of Hepatopancreatobiliary Surgery

基　　金：国家自然科学基金项目(81173267);上海市科委自然科学基金项目(11ZR1436800);国家教育部高等学校博士点基金项目(200802680005)

摘　　要：目的探讨中药升清胶囊对胆汁中重要的促成核蛋白α1-酸性糖蛋白(α1-acid glycoprotein,AAG)及生化指标的影响及其临床意义。方法对2007年6月至2009年3月期间收治的40例胆囊结石或肝内外胆管结石患者进行回顾性分析。术前经B超或CT等检查确诊。术中行胆道手术放置T管或行内镜逆行胰胆管造影和内镜鼻胆管引流。术后分为对照组(常规外科处理20例)和实验组(常规外科处理后口服升清胶囊20例),于术后1、3、5、14 d收集T管或ENBD胆汁,检测胆汁中AAG含量及生化指标——总胆红素、非结合胆红素、胆固醇、磷脂、总胆汁酸、钙离子等指标的变化。结果实验组患者服用升清胶囊后能明显降低患者胆汁中α1-酸性糖蛋白含量(P<0.05)。升清胶囊对患者胆汁中的总胆红素、非结合胆红素、胆固醇、钙离子的表达具有一定的抑制作用(P<0.05)。对患者胆汁中磷脂、总胆汁酸具有一定的上调作用(P<0.05)。结论升清胶囊能显著降低人体胆汁中强促成核蛋白AAG的含量,有效改善胆汁生化成分,抑制胆结石的形成。Objective To investigate effects and clinical significance of Chinese herbal drugs Shengqing capsuleon nucleoprotein α1-acid glvcoprotein and biochemical indicators of bile in patient with cholelithiasis. Methods A retrospective analysis was conducted in 40 patients with cholecvstolithiasis or cholangiolithiasis definitely dial, nosed by B-mode ultrasonic diagnostic equipment or computerized tomographv between June 2007 and March 2009. T tube was placed via biliarv drainage operation or ERCP＋ENBD in biliarv surgery. All patients were randomly divided into experimental group and control group, each group had 20 patients. Two groups received conventional treatments （including antibiotic treatments）, and experimental group took Shengqing capsule after the first day of operation, T tube patients took Shengqing capsule for 14 d, ENBD patients took Shengqing capsule for 5 d. Then, bile from T tube and ENBD were collected on 1st, 3rd, 5th, 14th after operation respectively, and α1-acid glvcoprotein, total bilirubin, un-coniujated bilirubin, cholesterol, phospholipid, total bile acid, calcium of bile were detected. Results Shengqing capsule reduced AAG in experimental group, there was a significant difference between two groups （P〈0.05）. Compared with control group, Shengqing capsule in experimental group reduced TBIL, UCB, CH, Ca2＋ （P〈0.05）, and increased PL, TBA of bile （P〈0.05）. Conclusion Shengqing capsule can reduce nucleoprotein AAG content in patients bile with cholelithiasis significantly, which improve biochemical indicators efficiently, and inhibit the formation of calculus in bile.

关 键 词：胆固醇结石 升清胶囊 促成核蛋白 Α1-酸性糖蛋白 胆汁生化指标 

分 类 号：R285[医药卫生—中药学]