通腑汤直肠高位滴注的临床研究  

Clinical Application and Experimental Study on Rectal High Instillation with Tongfutang

作　　者：倪孝儒[1] 李乃卿[1] 李雪蕾[1] 王滨[1] 周春宇[1] 解朴[1] 史晓光[1] 滕占庆[1] 

机构地区：[1]北京中医药大学东直门医院外科,北京100700

出　　处：《北京中医药大学学报》2000年第2期61-63,共3页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：通腑汤由大黄、芒硝、枳实、厚朴、陈皮、半夏、木香、乌药、川楝子、炒莱菔子、当归、白芍组成 ,具有通里攻下、行气理气兼以养血活血之功效。对腹部手术后患者分别给予通腑汤肛肠灌注、口服 ,并设高渗盐水直肠灌注为对照。结果 :通腑汤肛肠灌注组在肠鸣音恢复时间 ,体表胃窦、升结肠和降结肠体表肌电平均振幅及平均过零频率升高 ,血浆胃动素升高 ,血浆降钙素基因相关肽降低方面均优于口服组及盐水组。提示 :直肠灌注通腑汤的治疗机制与影响胃肠激素的调控有关 ,还可能与药物对肠神经系统的调控和The TCM decoction,Tongfutang,has the functions of removing stasis by purgation,circulating and regulating qi and nourishing the blood and activating the blood flow.It is composed of Dahuang,Mangxiao,Zhishi,Houpo,Chenpi,Banxia,Muxiang,Wuyao,Chuanlianzi,Chaolaifuzi,Danggui and Baishao.After abdominal operation,60 patients were randomly divided into 3 groups:anorectal group with Tongfutang instillation,oral group with Tongfutang orally taken and saline group with hypertonic saline irrigation.Results showed the effect of anorectal group surpassed the saline group and oral group.The differecnce is significant ( P <0 01).1 hour after administration,in anorectal group,there was some increase in the surface gastric antrum and the mean amplitude(Ap) and zero crossing frequency(Fz) of the surface myoelectricity of ascending colon and descending colon ( P <0 05).While in saline group,there's only increase in Ap and Fz of ascending and descending colon ( P <0 05),of which the range was significantly lower than that in the anorectal group ( P <0 01).Furthermore,in anorectal group,the level of plasma motilin(MOT) was increased( P <0 01) and the level of plasma calcitonin gene related peptide(CGRP) was decreased ( P <0 01).The saline group had no significant changes in the gastrointestinal hormone concentration before and after administration.It indicated that the therapy of rectal instillation with Tongfutang might correlate with regulating gastrointestinal hormone,also probably with effect of the drug on the myogenic and intestinal nervous systemic regulation.

关 键 词：通腑汤 直肠给药 肠鸣音 临床研究 腹部外科手术 

分 类 号：R269.56[医药卫生—中西医结合]