Coflex与传统手术方法治疗腰椎退行性疾病疗效的Meta分析  

Coflex versus posterior lumbar interbody fusion in the treatment of lumbar spine degenerative diseases:a Meta analysis

作　　者：赵海恩[1] 郭明君[1] 梅玉峰[1] 于洋 王育才[1] 马保安[1] 姬振伟[1] 范清宇[1] 

机构地区：[1]第四军医大学唐都医院骨科 [2]解放军93792医院

出　　处：《中国矫形外科杂志》2012年第23期2129-2134,共6页Orthopedic Journal of China

摘　　要：[目的]系统评价Coflex与传统融合固定两种手术方法治疗腰椎退行性病变的有效性和安全性。[方法]计算机检索数据库,手工检索骨科相关杂志,纳入关于Coflex与传统治疗腰椎退行性病变的研究并进行Meta分析。[结果]纳入12篇研究共684病例,Meta分析结果显示:Coflex与传统手术方法相比较,前者在手术时间和住院时间上短于后者,失血量少于后者,手术节段的ROM大于后者,差异具有统计学意义。后背VAS和JOA差异无统计学意义。[结论]在达到相同治疗效果的情况下,Coflex可以明显减少手术时间、术中出血量和住院时间,而且可以保持手术节段腰椎存在一定活动度,避免了邻近节段的退变,术后短期内随访显示了其生物力学上优越性。[ Objective] To analyze the efficacy and safety of Coflex versus posterior lumbar interbody fusion in the treat- ment of lumbar spine degenerative diseases such as LSS. [ Methods ] A systematic computer - based search of Medline, EM- BASE, Cochrance Central, and manual search of related journals were performed for collecting controlled trials. RevMan 5.1 software was used for meta analysis. [ Results ] Twelve studies involving a total of 684 patients were included. The meta - analy- sis indicated that statistically significance were noted between two procedures for the operation time, length of hospital stay, blood loss and range of motion of lumbar. While no differences were noted for the low back VAS, ODI and JOA. [ Conclusion] Both procedures were effective and safe in pain relief and functional recovery for lumbar spine degenerative diseases. Coflex could also shorten the operation time and length of hospital stay, decrease the blood loss. It showed that Coflex had biomechanical supe- riority in a short follow - up period.

关 键 词：Coflex动态内固定 腰椎退行性病变 META分析 

分 类 号：R687.3[医药卫生—骨科学]