强制戒断的海洛因成瘾者默认功能网络fMRI研究  

fMRI study of the default mode network in heroin-dependent patients during compulsory abstinence

作　　者：李强[1] 王亚蓉[1] 李玮[1] 朱佳[1] 郑颖[1] 王玮[1] 

机构地区：[1]第四军医大学唐都医院放射诊断科,陕西西安710038

出　　处：《实用放射学杂志》2012年第11期1665-1668,共4页Journal of Practical Radiology

基　　金：国家自然科学基金项目（81071142,81071143,81201081）;陕西省科技攻关项目（2009K0165,2010k16-03-01,2010K16-03-02）.

摘　　要：目的探讨强制戒断的海洛因成瘾者默认功能网络的异常。方法15例经强制戒断的海洛因成瘾者与15例年龄、受教育程度相匹配的健康受试者参加本研究。采用3．0T磁共振扫描仪进行静息态fMRI数据采集。用SPM8及GIFT软件分别进行数据预处理和独立成分分析以得到默认功能网络。用sPM8比较2组间默认功能网络差异。结果与健康受试者相比，海洛因成瘾者默认功能网络与抑制性控制相关脑区（双侧前扣带回、内侧前额叶），动机驱动相关脑区（右侧眶额回）以及左侧颞下回及小脑的功能连接度明显下降。未发现与海洛因成瘾者默认功能网络功能连接增强的区域。结论经过长期强制戒断的海洛因成瘾者大脑默认功能网络仍存在异常。抑制性控制及动机驱动相关脑区受损可能是海洛因成瘾者难以戒断的原因。Objective To investigate the characteristics of the default mode network in heroin-dependent patients during compulsory abstinence. Methods Fifteen former heroin-dependent patients during long-term compulsory abstinence and 15 demographically matched healthy subjects participated in this study. The resting-state functional magnetic resonance imaging （fMRI） data were ac- quired on a 3.0 T MRI scanner. The fMRI data were preprocessed with SPM8 and the independent component analysis was conduc- ted with GIFT software to derive the default mode network of each participant. The differences in default mode network between two groups were analyzed with SPM8. Results Compared with the healthy group, the heroin-dependent group demonstrated significant- ly decreased functional connectivity between the default mode network and the inhibitory control-related regions （bilateral anterior cingulate gyri and medial prefrontal cortex）, motivation-related region （right orbitofrontal cortex）, left inferior temporal gyrus and cerebellum. No significantly increased functional connectivity was found for the heroin-dependent group. Conclusion The abnormal- ities of the default mode network in heroin-dependent patients still remain despite long-term compulsory abstinence. The damage in the inhibitory control-related and motivationdrive-related regions may result in the difficulty for heroin-dependent patients in quitting addiction.

关 键 词：海洛因 静息态 独立成分分析 功能磁共振成像 

分 类 号：R996[医药卫生—毒理学] R445.2[医药卫生—药学]