晚期妊娠引产产妇及其新生儿血浆中的米非司酮浓度测定  

HPLC Assay for Mifepristone in Plasma of Parturient and Their Newborns

作　　者：高晨[1] 赵志刚[1] 王越[1] 罗劲松[1] 任淑萍[1] 

机构地区：[1]北京天坛医院,100050

出　　处：《药物分析杂志》2000年第2期119-121,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的 :研究米非司酮用于晚期妊娠引产对新生儿的影响 ,评价其对母婴的安全性。方法 :采用高效液相色谱法测定产妇及新生儿血浆中的米非司酮浓度。结果 :服药组产妇产程活跃期血浆中的米非司酮浓度为 ( 3 2 3± 13 7)ng·mL-1、脐血浓度为 ( 95 9± 5 1 0 )ng·mL-1,其新生儿出生后 2 4h的血药浓度为 ( 3 9 8± 2 0 7)ng·mL-1,均与对照组有显著差异 (P <0 0 5 ) ,且脐血浓度与产妇产程活跃期血浆中的米非司酮浓度成正相关 ,相关系数为 0 72 ,脐 /母血药浓度比值为 0 3 0。出生后 72h血药浓度 ( 2 7 7± 9 9)ng·mL-1与对照组比无显著差异 (P >0 0 5 )。结论Objective:To study the effect upon the newborns after the parturient treatment with mifepristone.Methods:The concentration of mifepristone in the plasma of parturient,their newborns and umbilical cord was assayed with HPLC.Results:After administrated with mifepristone, the parturient, umbilical plasma level and their newborns’ plasma concentration 24 h and 72 h after their birth were detected to be (323±137)ng·mL -1 , (95 9±51 0)ng·mL -1 ,(39 8±20 7)ng·mL -1 ;compared with control group, the difference were statistically significant; and 72 h after their birth was (27 7±9 9)ng·mL -1 , there wasnt significant difference with control group ;the umbilical plasma concentration had positive correlation with the maternal, the ratio of umbilical/maternal mifepristone level was 0 30,the correlation coefficient was 0 72.Conclusion:This study will provide a scientific basis for the safety of using mifepristone on parturient

关 键 词：米非司酮 HPOLC 妊娠晚期 新生儿 药物引产 

分 类 号：R719.31[医药卫生—妇产科学] R969.1[医药卫生—临床医学]