血管活性物质在妊高征发病中的作用  

The Role of Vaso active Substance in the Patients with Pregnancy Induced Hypertension

作　　者：王晨虹[1] 肖根秀[1] 赵柏程[1] 卢放根[1] 左泽志[1] 罗建清[1] 

机构地区：[1]湖南医科大学第二附属医院,湖南长沙410011

出　　处：《实用妇产科杂志》2000年第2期87-89,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的 :探讨一氧化氮 (NO)、内皮素 - 1(ET- 1)、前列环素 (PGI2 )、血栓素 A(TXA2 )、降钙素基因相关肽(c GRP)多种血管活性物质对妊高征发病的影响。方法 :应用放射免疫法测定 6 0例妊高征患者 ,2 3例正常妊娠妇女血浆ET- 1、PGI2 、TXA2 、c GRP浓度 ,用 Griess法测定 NO浓度。结果 :1妊高征患者血浆 NO、PGI2 、c GRP浓度降低 ,NO与妊高征病情呈负相关 ,PGI2 、c GRP与中、重度妊高征病情呈负相关。 2妊高征患者血浆 ET- 1、TXA2 浓度增高 ,ET- 1与妊高征病情呈正相关。,TXA2 与中、重度妊高征病情呈正相关。 3上述 5种血管活性物质相关分析 ,NO与 ET- 1、TXA2 与中、重度妊高征呈负相关 ,NO与 PGI2 、c GRP呈正相关 ,ET- 1与 PGI2 、c GRP呈负相关。结论 :1NO、ET- 1、PGI2 、TXA2 、c GRP可做为判断妊高征病情的指标。 2多种血管活性物质在妊高征发病中具有协同和拮抗作用。Objective:To study the role of Nitric oxide(NO),Endothelin-1(ET-1),prostacyclin(PGI 2),Thromboxane(TXA 2),Calcitonin gene relatd peptide(cGRP)in the patients with pregnancy induced hypertension(PIH).Methods:Plasma ET-1,PGI 2,TXA 2,cGRP were studied by immunoradiological method in 60 patients with PIH; plasma NO were measured with Griess assay.Results:The results showed that①the levels of plasma NO,PGI 2,cGRP in patients with PIH were decreased significantly than those in healthy pregnant women.②the levels of plasma ET-1,TXA 2in patients with PIH were significantly higher than those in healthy pregnant women.③There are negative correlation between NO and ET 1,TXA 2 in patients with moderate and severe PIH;There are positive correlation between NO and PGI 2,cGRP in patients with moderate and severe PIH.Conclusion:The resuts suggest that. ①plasma NO,ET-1,PGI 2,TXA 2,cGRP concentration could be used as a relible indicator of the sever of PIH.②many vascular active factors produce synergism and antagonism in PIH.③the cause and pathogenesis of PIH could be caused by many ways.

关 键 词：妊娠高血压 综合征 血管活性物质 内皮素1 NO 

分 类 号：R714.246[医药卫生—妇产科学]