大黄不同提取液的成膜材料筛选  

To screen the film-forming materials of different extracts of Rheum palmatum L.

作　　者：林华燕[1] 魏刚[1] 何坦 刘东辉[1] 许日鑫[1] 林微微[1] 石添香[1] 欧斯健[1] 

机构地区：[1]广州中医药大学新药开发研究中心,广东广州510006 [2]广州中一药业有限公司,广东广州510130

出　　处：《广东药学院学报》2012年第5期470-474,共5页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省教育部产学研结合项目(2011B090400319);广东高校科技成果转化重大项目(cgzhzd1009);国家科技部"十一五"科技支撑计划项目(2008BAI53B074)

摘　　要：目的考察主要成膜材料在大黄的水提液及不同体积分数乙醇提取液中的成膜性能,为含大黄的中药制剂成膜材料的选择与应用提供参考。方法根据成膜材料的溶解性,选择加入聚乙烯吡咯烷酮(PVP)、聚乙烯醇(PVA)、乙基纤维素(EC)、甲基纤维素(MC)、聚乙烯醇缩丁醛(PVB)等成膜材料,通过显微镜和图像拍摄软件对膜结构进行分析。结果 PVP-K30在大黄的水提液以及不同体积分数的乙醇提取液中具有良好的成膜性,且膜的质地细密、光滑、平整;PVP-K90在大黄各提取液中均能成膜,但在大黄40%、60%乙醇提取液中成膜性较差。PVA-17-88在大黄各提取液中均能成膜,但膜的表面凹凸不平、较粗糙,有少量颗粒分散。EC在大黄的无水乙醇提取液中成膜性能优良,能形成1层厚实、平整、致密的膜。MC在大黄提取液中的成膜性随提取液乙醇体积分数的升高而降低。PVB只在大黄的无水乙醇提取液中成膜。结论成膜材料的选择与大黄提取液溶媒的极性相关;PVP-K30在大黄的水提液和不同体积分数乙醇提取液中成膜性均较好,是含大黄中药喷膜剂的优选成膜材料。Objective To screen out the appropriate film-forming materials of Rheum palmatum L.extracts as a reference for the consperg film agent.Methods According to the results of the dissolving experiments of the film-forming materials,polyvinyl pyrrolidone（PVP）,polyvinyl alcohol（PVA）,ethyl cellulose（EC）,methyl cellulose（MC） and polyvinyl butyral（PVB） were used to test their film-forming properties in the different extracts of Rheum palmatum L.by analyzing the filming photos which were screened by the microscope and photo software.Results The film properties of PVP-K30 in the extracts of the Rheum palmatum L.were very fine.PVP-K90 could film,but was poor in the extraction solution of 40%（φ） ethanol and 60%（φ） ethanol.PVA-17-88 could film,but the membrane surface was uneven and rough.EC could form a favorable film in absolute ethyl alcohol extract of Rheum palmatum L..The solubility and film-forming properties of MC became worse and worse as the concentration of ethanol solution increased.PVB could form a film only in absolute ethyl alcohol extract of Rheum palmatum L..Conclusion The polarity of solvent showed a greater effect on the film-forming materials.The film-forming properties of PVP-K30 were fine in the different extracts of the Rheum palmatum L.,so it was the best choice for the consperg film agent in film-forming materials.

关 键 词：中药喷膜剂 大黄提取液 成膜材料 成膜性能 

分 类 号：R283[医药卫生—中药学]