芦丁铬(Ⅲ)配合物的合成、表征及其抗氧化活性研究  

The synthesis,characterization and antioxidant properties of rutin-chromium(Ⅲ) complexes

作　　者：杨武群[1] 吕华冲[1] 蔡金艳[1] 高奥[1] 周鹏飞[1] 王平[1] 王健壮[1] 

机构地区：[1]广东药学院药科学院,广东广州510006

出　　处：《广东药学院学报》2012年第5期493-496,共4页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的合成芦丁-铬(Ⅲ)配合物后对其进行表征,并研究其抗氧化活性。方法以芦丁为先导化合物与微量元素铬合成芦丁-铬(Ⅲ)配合物。通过红外光谱、紫外可见光谱、元素分析、热重分析和原子吸收光谱对配合物进行表征。采用羟自由基(.OH)和超氧自由基(O2-.)模型测定了芦丁和芦丁-铬(Ⅲ)配合物的抗氧化活性。结果与结论确定芦丁-铬(Ⅲ)配合物中芦丁与铬的摩尔比为1∶1,推测分子式为CrCl2C27H32O18.7H2O。芦丁-铬(Ⅲ)配合物抗氧化作用比芦丁配体强。Objective To synthetize and characterize rutin-chromium（Ⅲ） complexes,and detect its antioxidation activities.Methods Rutin was taken as a lead compound,synthesized with trace element chromium and obtained rutin-chromium（Ⅲ） complexes.The complexes were confirmed by IR,UV-Vis,elemental analysis,thermo gravimetric analysis and atomic absorption spectrometric.Meanwhile,the antioxidation activities were investigated by hydroxyl radicals（·OH） and superoxide radicals（O-2·）.Results and Conclusion The molar ratio between rutin and chromium is 1∶1.The structural formula is inferred as CrCl2C27H32O18·7H2O.The antioxidation activities results demonstrate that rutin-chromium（Ⅲ） complexes is stronger than rutin on the antioxidation activities.

关 键 词：芦丁 铬 金属配合物 氧自由基 

分 类 号：R284.1[医药卫生—中药学]