复方双氯芬酸辣椒凝胶贴膏的抗炎镇痛作用与毒性反应  

Anti-inflammatory and Analgesic Effects and Toxicity of Compound Diclofenac Capsaicin Cataplasms

作　　者：陈鹰[1] 陈湖海[1] 徐腾[2] 杜蓉[1] 李佳芝[1] 朱晓雯[1] 朱以良[1] 

机构地区：[1]广州军区武汉总医院,武汉430070 [2]广州军区联勤部药品仪器检验所

出　　处：《中国药师》2012年第10期1434-1437,共4页China Pharmacist

摘　　要：目的:研究复方双氯芬酸辣椒凝胶贴膏的抗炎镇痛作用及毒性反应。方法:采用二甲苯致炎法、醋酸扭体法和热板法,观察复方双氯芬酸辣椒凝胶贴膏局部给药对小鼠的抗炎镇痛作用。并考察大鼠的皮肤急性毒性和家兔皮肤刺激性。结果:复方双氯芬酸辣椒凝胶贴膏能显著抑制小鼠耳肿胀度,小鼠醋酸扭体反应和热板舔足反应;大鼠皮肤给药的无明显损害作用剂量为200 mg·kg-1,家兔皮肤给药对完整皮肤组无刺激性,对破损皮肤有轻度刺激性。结论:复方双氯芬酸辣椒凝胶贴膏可用于局部疼痛炎症的治疗,临床剂量下是安全的,但应慎用于破损皮肤。Objective： To study the anti-inflammatory and analgesic effects and toxicity of compound diclofenac capsaicin cataplasms（CDCC）.Method： The anti-inflammatory and analgesic effects of CDCC on mice were researched by dimethyl-benzen induced ear oedema model,acetic acid induced writhing model and hot plate method.The acute toxicity of CDCC was studied in rats and the irritation test was observed in rabbits.Result： The ear swelling degree was inhibited significantly by CDCC.The writhing reaction induced by acetic acid was inhibited and the pain threshold induced by hot plate was raised significantly in mice.The dosage with no significant toxicity in rats was 200 mg·kg-1.Irritant symptoms were not significant in the integral skin,while mild irritation was shown in the damaged skin of rabbits.Conclusion： CDCC can be used in the treatment of local pain inflammation and the clinical dosages are safe,while attention should be paid for the use in damaged skin.

关 键 词：复方双氯芬酸辣椒凝胶贴膏 抗炎作用 镇痛作用 急性毒性 刺激性 

分 类 号：R965.1[医药卫生—药理学]