维E甘草霜的质量控制  

Quality Control of Vitamin E and Glycyrrhetate Creams

作　　者：胡晓[1,2] 陈鹰[1] 郑建灵[3] 董少华[1,2] 

机构地区：[1]广州军区武汉总医院,武汉430070 [2]湖北中医药大学 [3]南方医科大学

出　　处：《中国药师》2012年第10期1447-1449,共3页China Pharmacist

摘　　要：目的:制备维E甘草霜并建立其质量控制方法。方法:以HPLC法测定主药维生素E与甘草酸单铵盐的含量。结果:维生素E质量浓度在8.3～41.6μg·ml-1范围内线性关系良好(r=0.999 9),平均加样回收率为99.20%;甘草酸单铵盐质量浓度在8.0～40.0μg·ml-1范围内线性关系良好(r=0.999 9),平均加样回收率为97.85%。结论:建立的方法简便可行,结果准确可靠,可用于维E甘草霜的质量控制。Objective： To prepare vitamin E and glycyrrhetate creams and establish the quality control method.Method： An HPLC method was used to determine vitamin E and glycyrrhetate in the creams.Result： The linear concentration range of vitamin E was 8.3-41.6 μg·ml-1（r=0.999 9） with the recovery of 99.20%.The linear concentration range of glycyrrhetate was 8.0-40.0 μg·ml-1（r=0.999 9）with the recovery of 97.85%.Conclusion： The method is simple and practical,the result is accurate and reliable,suggesting a promising method for the quality control of vitamin E and glycyrrhetate creams.

关 键 词：维生素E 甘草酸单铵盐 高效液相色谱法 乳膏剂 

分 类 号：TQ460.72[医药卫生—药物分析学]