In Vitro Activity and Postantibiotic Effect of Tulathromycin against Actinobacillus pleuropneumonia  

作　　者：BAI Ru-nian LI Zhi-yuan WU Cong-ming ZHOU Lei CAO Xing-yuan 

机构地区：[1]Beijing Animal Husbandry and Veterinary Station, Beijing 100107, China [2]Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China

出　　处：《Animal Husbandry and Feed Science》2010年第8期32-33,共2页动物与饲料科学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (30700604)

摘　　要：The postantibiotic effect （PAE） is defined as the suppression of bacterial growth persisting after a short exposure of bacterial cultures to an antibiotic. This phenomenon has obvious clinical interest, because antibiotic agents which produce extensive PAEs could be administrated less frequently without reducing efficacy. The minimum inhibitory concentration （MIC） and PAE of tulathromycin and erythromycin on five isolates of Actinobacillus pleuropneumonia were determined. All strains were susceptible to tulathromycin （ MIC： 0.25 - 1.00 μg/ml） and resistant to erythromycin （MIC： 32 -128 μg/ml）. The mean PAEs of 1 xMIC, 2 xMIC, 4 xMIC and 8 xMIC of tulathromycin against the tested isolates were 0.62, 1.53, 2.70 and 4.50, respectively. These results indicated that tulathromycin might be administered at longer time intervals than those already applied. This is in tavorite of the clinical rational use of antimicrobial druqs.The postantibiotic effect （PAE） is defined as the suppression of bacterial growth persisting after a short exposure of bacterial cultures to an antibiotic. This phenomenon has obvious clinical interest, because antibiotic agents which produce extensive PAEs could be administrated less frequently without reducing efficacy. The minimum inhibitory concentration （MIC） and PAE of tulathromycin and erythromycin on five isolates of Actinobacillus pleuropneumonia were determined. All strains were susceptible to tulathromycin （ MIC： 0.25 - 1.00 μg/ml） and resistant to erythromycin （MIC： 32 -128 μg/ml）. The mean PAEs of 1 xMIC, 2 xMIC, 4 xMIC and 8 xMIC of tulathromycin against the tested isolates were 0.62, 1.53, 2.70 and 4.50, respectively. These results indicated that tulathromycin might be administered at longer time intervals than those already applied. This is in tavorite of the clinical rational use of antimicrobial druqs.

关 键 词：TULATHROMYCIN Actinobacillus pleuropneumonia Postantibiotic effect 

分 类 号：TQ330.43[化学工程—橡胶工业] S858.28[农业科学—临床兽医学]