Synthesis of 4-methyl Guanidine Butyric Acid  

4-甲基胍基丁酸的合成研究(英文)

作　　者：韦鹏[1] 郭睿[1] 孙江[1] 来肖[1] 赵艳艳[1] 孙靖 

机构地区：[1]陕西科技大学教育部轻化工助剂化学与技术重点实验室,陕西西安710021 [2]西安三业精细化工有限责任公司,陕西西安710075

出　　处：《Plant Diseases and Pests》2010年第5期64-66,共3页植物病虫害研究（英文版）

摘　　要：N-methyl pyrrolidone,hydrochloric acid and thiourea dioxide were adopted as the raw material,and 4-methyl guanidine butyric acid was synthesized through two-step reaction.The optimum synthesis condition for the first step was as follows：n（N-methyl pyrrolidone）∶n（10% HCl）= 1∶2.0,reaction temperature 135 ℃,reaction time 5 h;at that moment,the yield of intermediate 4-methyl-amino butyric acid hydrochloride was 72.89%.The optimum synthesis condition for the second step was as follows：n（4-methyl-amino butyric acid hydrochloride）∶n（thiourea dioxide）= 1∶2.0,reaction temperature 25 ℃,reaction time 12 h,at that moment,the yield of target product was 82.68%.Structure characterization on the intermediates and the target products were carried out through Fourier transform infrared spectroscopy and elemental analysis.N-methyl pyrrolidone,hydrochloric acid and thiourea dioxide were adopted as the raw material,and 4-methyl guanidine butyric acid was synthesized through two-step reaction.The optimum synthesis condition for the first step was as follows：n（N-methyl pyrrolidone）∶n（10% HCl）= 1∶2.0,reaction temperature 135 ℃,reaction time 5 h;at that moment,the yield of intermediate 4-methyl-amino butyric acid hydrochloride was 72.89%.The optimum synthesis condition for the second step was as follows：n（4-methyl-amino butyric acid hydrochloride）∶n（thiourea dioxide）= 1∶2.0,reaction temperature 25 ℃,reaction time 12 h,at that moment,the yield of target product was 82.68%.Structure characterization on the intermediates and the target products were carried out through Fourier transform infrared spectroscopy and elemental analysis.

关 键 词：GUANIDINE FUNGICIDE N-methyl pyrrolidone Hydrochloric acid Thiourea dioxide 

分 类 号：TQ450.1[化学工程—农药化工]