仿生人工骨修复材料研究  

Biomimetic Artificial Bone Repair Materials: a Review

作　　者：王迎军[1,2] 杜昶[1,2] 赵娜如[1,2] 叶建东[1,2] 陈晓峰[1,2] 

机构地区：[1]华南理工大学材料科学与工程学院,广东广州510640 [2]华南理工大学国家人体组织功能重建工程技术研究中心,广东广州510006

出　　处：《华南理工大学学报（自然科学版）》2012年第10期51-58,共8页Journal of South China University of Technology(Natural Science Edition)

基　　金：国家"973"计划项目(2012CB619100;2011CB606204);国家自然科学基金资助项目(50830101;51072056);NSFC-广东省自然科学联合基金资助项目(U0834003)

摘　　要：骨缺损修复材料是临床需求量最大的生物医用材料之一.自体骨和异体骨移植的局限性使得研发优异的人工骨修复材料意义重大.通过模仿天然骨本身的成分、结构特性及生物矿化过程,对材料的组成、结构进行设计与调控,可以获得新型仿生人工骨修复材料,这已成为生物材料发展的主要趋势之一.文中概述了仿生人工骨修复材料的研究进展,重点介绍本课题组的相关研究,即类骨微纳米磷酸钙矿物的仿生合成、生物医用高分子仿生纳米纤维支架的制备和具有多级孔结构的自固化磷酸钙基骨修复材料的构建.The bone repair material is one of the biomedical materials with the highest clinical demand. Owing to the limitations of autograft and allograft transplantation, the development of advanced artificial bone repair materials proves to be of great significance. Novel biomimetic artificial bone repair materials can be produced by mimicking the composition and structure characteristics of natural bone and its biomineralization to design and regulate the composition and structure of the material, which has become one of the major trends in the development of biomate- rials. This paper summarizes the research progress of the biomimetic artificial bone repair materials, with the focus on the authors＂ studies on the biomimetic synthesis of bone-like nanoseale calcium phosphate minerals, the fabrica- tion of biomedical polymeric biomimetic nanofibrous scaffold, and the construction of the self-setting calcium phos- phate cements-based bone repair materials with biomirnetic porous structure.

关 键 词：生物医用材料 骨修复材料 生物矿化 仿生合成 

分 类 号：R318.08[医药卫生—生物医学工程]