加兰肽在前列腺癌组织中的表达及其意义  

Expression of galanin in the prostate carcinoma and its significance

作　　者：孙延波[1] 孙小庆[1] 高健刚[1] 李奎[1] 侯四川[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院泌尿外科,266071

出　　处：《肿瘤研究与临床》2012年第11期758-759,762,共3页Cancer Research and Clinic

摘　　要：目的研究加兰肽（GLA）在前列腺癌组织中的表达及其临床意义。方法采用免疫组织化学法检测GLA在50例前列腺增生、50例前列腺癌和30例发生骨转移的前列腺癌组织中的表达。结果GLA在前列腺增生、前列腺癌及骨转移前列腺癌组织中阳性表达率分别为18％（9／50）、68％（34／50）和80％（24／30），前列腺癌及骨转移组阳性表达率高于前列腺增生组，组间比较差异有统计学意义（χ^2值分别为25．5、29．74，均P〈0．01），但骨转移组与前列腺癌组阳性表达率比较差异无统计学意义（χ^2=1．35，P〉0．05）。结论GLA在前列腺癌组织中有较高表达，可作为良恶性前列腺疾病的鉴别指标，为前列腺癌的诊断及预测预后提供一定依据。Objective To study the expression and significance of galanin （GLA） in the prostate carcinoma （PCa）. Methods The samples from 50 patients with benign prostatic hyperplasia （BPH） and 50 patients with PCa and 30 PCa patients with bone metastasis were examined by immunohistochemical staining. Results The positive rates of GLA expression in BPH, PCa, and PCa with bone metastasis were 18 % （9/ 50）, 68 % （34/50）, and 80 % （24/30）, respectively, and there were statistically significant differences between PCa patients, PCa patients with bone metastasis and BPH patients （χ^2 = 2515, 29.74, both P 〈 0.01）, but there was no significant difference between PCa patients and PCa patients with bone metastasis （χ^2 = 1.35, P 〉 0.05）. Conclusion GLA has higher expression in prostatic cancer cells, it might be an important indicators for differentiating prostate cancer from benign prostatic hyperplasia and predicting the prognosis of prostate carcinoma.

关 键 词：前列腺肿瘤 加兰肽 骨转移 

分 类 号：R737.25[医药卫生—肿瘤]