二甲双胍治疗合并胰岛素抵抗的多囊卵巢综合征患者68例疗效观察  

Efficacy Observation of Metformin for 68 Cases of Polycystic Ovary Syndrome Complicated Insulin Resistance

作　　者：夏丽伟[1] 王永莉[1] 罗正琴[1] 

机构地区：[1]南方医科大学附属小榄人民医院妇产科,中山528415

出　　处：《中国医药导刊》2012年第10期1773-1774,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨二甲双胍治疗合并胰岛素抵抗的多囊卵巢综合征临床疗效。方法:将136例合并胰岛素抵抗的多囊卵巢综合征患者随机分为治疗组和对照组各68例。对照组予以达英-35治疗,每晚睡前口服1片,于月经第5日开始服药,连续服用21日,停药后月经来潮,再待月经第5日开始下一个疗程。治疗组在对照组基础上加用二甲双胍治疗,每次500毫克,每日3次,于撤退性出血或月经周期的第1日开始服药。连续治疗3个月后评价疗效。结果:两组患者治疗后卵巢体积、BMI、T、LH、FPG、FINS及胰岛素抵抗指数(IR)均有不同程度改善,与治疗前比较,差异均有统计学意义(P<0.05,或P<0.01)。治疗后治疗组卵巢体积、BMI、T、LH、FPG、FINS及IR均优于对照组,差异有统计学意义(P<0.05,或P<0.01)。结论:二甲双胍在常规达英-35治疗基础上应用能够有效降低T、LH及胰岛素水平,改善胰岛素抵抗。Objective：Explore the efficacy of metformin in treatment of polycystic ovary syndrome complicated with insulin resistance.Methods：136 cases of polycystic ovary syndrome complicated with insulin resistance were equally and randomly distributed into treatment group and control group.The control group received Diane-35 orally at bedtime every night,from the 5th day of the menstrual cycle,for 21 days,till the start of the next cycle,all over again on the 5th day of the next menstrual cycle.In addition to Diane-35 for control group,the treatment group also receives metformin,500mg 3 times a day,starting from the day of withdrawal bleeding or 1st day of menstrual cycle.Efficacy was evaluated after 3 consecutive months of treatment.Results：Ovarian volume,BMI,and T,LH,FPG,FINS and IR of both groups all had appreciated improvement after treatment,and the differences are all significant（P0.05,or P0.01）.After treatment,the ovarian volume,BMI,T,LH,FPG,FINS and IR of treatment group were all significantly better than those of control group（P0.05,or P 0.01）.Conclusion：Metformin in addition to conventional Diane-35 can reduce levels of T,LH and insulin and mitigate insulin resistance.

关 键 词：多囊卵巢综合征 胰岛素抵抗 二甲双胍 

分 类 号：R711.75[医药卫生—妇产科学]