运动对骨形态发生蛋白6介导的机体铁代谢调节机制的研究进展  

Regulatory Mechanism of Bone Morphogenetic Proteins 6 on Iron Metabolism During Exercise

作　　者：孙娟[1,2] 王海涛[1] 刘玉倩[1] 王羽[1] 王金霞[1] 

机构地区：[1]河北师范大学体育学院,河北石家庄050024 [2]河南省开封县朱仙镇一中,河南开封475131

出　　处：《河北师范大学学报（自然科学版）》2012年第6期644-648,共5页Journal of Hebei Normal University：Natural Science

基　　金：国家自然科学基金(30700390);河北省自然科学基金(C2009000291)

摘　　要：骨形态发生蛋白6(BMP6)为TGF-β超家族中一员,它产生于骨髓源性间质干细胞(BMSC)及造血干细胞,是一种调节成骨细胞和成软骨细胞分化的骨生长因子,在骨缺损的修复中具有重要作用.运动可促进BMP6的表达.研究发现,BMP6也是铁调素的重要的内源调节子,可以上调铁调素的表达,而铁调素是肠铁吸收的负调节子.因此,运动引起的BMP6表达增加,可以促进机体铁的吸收和释放,从而对运动中维持机体铁的动态平衡有重要的调控作用.Bone morphogenetic protein 6（BMP6） is a member of the transforming growth factor-β family,it is produced by bone marrow-mesenchymal（BMSC） and hematopoietic stem cells.BMP6is a potent protein for future treatment strategies of bone regeneration as it is a very important regulator of bone homeostasis and is a kind of adjusting the osteoblast and cartilage cells of bone growth factors.Moreover,it is also released by osteoclasts as a key bone coupling factor recruiting osteoblasts to the resorption site.So it has a good application potential in all kinds of bone defect repair.Sports can promote expression of BMP6.Recent study shows that BMP6can up-regulation of hepcidin expression.However,hepcidin is the negative regulators and down-regulation of intestinal iron absorbing.So exercise-induced increased expression of BMP6and promotes iron absorption and release.Consequently,to maintain iron homeostasis in the sport has an important regulatory role.

关 键 词：骨形态发生蛋白6 铁调素 铁代谢 

分 类 号：G804.547[文化科学—运动人体科学]