microRNA在乙型、丙型肝炎中的作用  

Functional role of microRNAs in viral hepatitis infections

作　　者：胡学玲[1] 范公忍[1] 

机构地区：[1]北京军区总医院全军肝病治疗中心,北京100700

出　　处：《临床肝胆病杂志》2012年第11期877-880,共4页Journal of Clinical Hepatology

摘　　要：近年来,作为基因表达的重要调节因子microRNA(miRNA),以及与这些miRNA关联或调控的各种肝脏疾病,如肝炎、肝纤维化和肝细胞癌(HCC)等方面的研究取得了新进展。许多编码miRNA的基因及其靶标被发现,它们与肝脏疾病的直接或间接的关联性也通过大量的实验研究(包括人体组织)得到确证。病毒性肝炎是由多种不同肝炎病毒引起的一组以肝脏损伤为主的传染病,根据病原学诊断,肝炎病毒至少有5种,但目前最常见的是HBV和HCV感染。本文就miRNA与病毒性肝炎的关系研究进展作一综述。Since their discovery in the 1990s,microRNAs（miRNAs） have been characterized as important regulators of gene expression,mediating normal physiological processes and pathogenesis-related mechanisms,as well as being amenable to exogenous manipulation to elicit therapeutic effects.The roles of miRNAs in liver diseases,such as liver fibrosis,viral hepatitis,and hepatocellular carcinoma（HCC）,have been extensively studied.Many of the liver disease-associated miRNA-encoding genes and their downstream targets have been identified,and their direct or indirect relationship with specific disease types and stages have been confirmed both in vitro and in vivo using animal models and human tissues.Viral hepatitis is one of the most prevalent infectious diseases worldwide and a principal cause of liver damage,liver failure,and mortality associated with liver disease.At least five hepatitis viruses commonly infect humans,but hepatitis B virus（HBV） and hepatitis C virus（HCV） account for the majority of cases.Research efforts aimed at understanding the pathogenesis of and host response to hepatitis viruses have focused on the role of endogenous miRNAs in these processes.This review article presents the recent findings concerning the relationship between miRNA and viral hepatitis and discusses the implications of those findings for future development of miRNA biomarker-based diagnostic,prognostic,and therapeutic strategies.

关 键 词：微RNAS 病毒性肝炎 

分 类 号：R512.62[医药卫生—内科学]