中枢神经兴奋药物莫达非尼的合成  

Synthesis of Central Stimulant Drug: Modafinil

作　　者：李德鹏[1,2] 史云争[1,2] 张晓辉[1,2] 黄秉奂[1,2] 王爱玲[1,2] 

机构地区：[1]大连大学环境与化学工程学院,辽宁大连116622 [2]大连大学辽宁省生物有机化学重点实验室,辽宁大连116622

出　　处：《大连大学学报》2012年第6期89-92,共4页Journal of Dalian University

摘　　要：莫达非尼是一种新型的中枢神经精神兴奋药物,毒副作用小,Lafon公司首先报道了莫达非尼的合成路线。改进了莫达非尼合成路线,优化了合成工艺条件,大大地缩短了反应时间,反应条件温和,合成操作简便。主要产物用IR、MS、1H-NMR表征了结构。Modafinil is a novel central stimulant drug and relatively small in side effects. The synthetic route of Modafinil is firstly reported by Lafon. This paper improved synthetic route of modafinil, and optimized the synthetic conditions. The reaction time was greatly shortened, the reactions condition was mild and the operation of synthesis was simple in this paper. Key products are characterizated by IR, MS and 1H-NMR.

关 键 词：莫达非尼 莫达非尼酸 兴奋药物 

分 类 号：R971[医药卫生—药品]