Sinularia sp.中化学成分的分离与结构鉴定  

Isolation and Structural Identification of Chemical Constituents from Sinularia sp.

作　　者：吕芳[1] 迟凯月[1] 戴荣继[1] 邓玉林[1] 

机构地区：[1]北京理工大学生命学院,北京100081

出　　处：《北京理工大学学报》2012年第10期1096-1100,共5页Transactions of Beijing Institute of Technology

基　　金：国家教育部高等学校博士学科点专项科研基金资助项目(新教师课题基金资助项目;20091101120045)

摘　　要：利用硅胶色谱、凝胶色谱等分离方法从软珊瑚Sinularia sp.中分离得到6种化学成分.通过一维核磁共振波谱、二维核磁共振波谱和质谱等分析方法对化合物进行结构解析,确定为西松烷二萜类成分:lobocrassolide,lobo-hedleolide,(7Z)-lobohedleolide和2-epi-11Z-lobohedleolide;邻笨二甲酸酯类成分:1,2-benzenedicarboxylic acid di-isobutyl ester;甾醇类成分:ergosta-5-en-3β-ol.其中4种西松烷二萜类化合物为首次从该样品中获得.Six constituents were repeatedly isolated and purified from a soft coral Sinularia sp. by silica gel and Sephadex LH 20 chromatographies. On the basis of spectroscopic data of 1D NMR, 2D NMR and EI-MS, their chemical structures were identified as lobocrassolide, lobohedleolide, （TZ）-lobohedleolide, 2-epi-11Z-lobohedleolide, 1, 2-benzenedicarboxylic acid diisobutyl ester, ergosta-5-en-3β-ol. The compounds of cembranoid diterpenes are gained from this organism for the first time.

关 键 词：软珊瑚 西松烷二萜 化学成分分离 结构鉴定 

分 类 号：R931.7[医药卫生—生药学]