抗凝血酶Ⅲ测定在血栓形成性疾病中的诊断价值  

Measurement of Human Plasma Antithrombin-Ⅲ in Thrombosis Diseases

作　　者：李金泉[1] 江一民[1] 吴翼伟[1] 崔岗[1] 张海涛[1] 苏成海[1] 张玮[1] 

机构地区：[1]苏州医学院附属一院,苏州215006

出　　处：《苏州医学院学报》2000年第6期541-542,共2页Acta Academiae Medicinae Suzhou

基　　金：中国核工业总公司基金!资助项目 (A91- 11)

摘　　要：目的　评价抗凝血酶Ⅲ (AT -Ⅲ )浓度的测定对血栓形成性疾病的诊断价值。方法　采用放射免疫分析法测定 2 3例重度肝病和 2 6例深静脉血栓形成患者血浆AT -Ⅲ浓度。并与 47名正常人进行对照。结果　 2 3例重度肝病和 2 6例深静脉血栓形成患者血浆AT -Ⅲ浓度分别为 90 .5± 16 .4mg/L和 15 4.3± 31.1mg/L。均低于正常参考值 ,与对照组相比有显著性差异 (P <0 .0 1)。结论　血浆中AT -Ⅲ水平的测定有助于血栓形成性疾病的诊断。Purpose To evaluate the significance of human plasma antithrombin Ⅲ(AT-Ⅲ) level for the diagnosis of thrombosis diseases.Methods Human plasma AT-Ⅲ level was determined by AT-Ⅲ RIA in 23 cases of liver diseases and 26 cases of deep vein thrombosis.Forty Seven cases of health volunteers were laken as the control.Results Patients with liver diseases and deep vein thrombosis had low AT-Ⅲ levels (90.5±16.4μg/ml and 154.3±31.1μg/ml respectively).Differences between patients and the subjects in control group was significant.Conclusions The results suggest that measurement of AT-Ⅲ level is valuable for the diagnosis of thrombosis diseases.

关 键 词：抗凝血酶Ⅲ 放射免疫分析 血栓形成 

分 类 号：R543.04[医药卫生—心血管疾病] R446.112[医药卫生—内科学]