多组分分析程序测定复方洗必泰溶液含量  

Determination of compound hibitane solution by multicomponent analysis program

作　　者：陈鸣[1] 林伊梅[1] 

机构地区：[1]新疆医科大学第二附属医院药剂科,新疆乌鲁木齐830028

出　　处：《新疆医科大学学报》2000年第2期143-144,共2页Journal of Xinjiang Medical University

摘　　要：目的 :建立同时测定复方醋酸洗必泰溶液中甲硝唑和醋酸洗必泰二组分的分析方法。方法 :用多组分分析程序测定复方醋酸洗必泰溶液中二组分的含量。结果 :甲硝唑在 319nm处 ,浓度在 3～ 16 μg/ ml范围吸收度与浓度呈良好的线性关系 ;醋酸洗必泰在 2 5 3nm处 ,浓度在 3～ 18μg/ ml范围吸收度与浓度呈良好的线性关系 ,平均回收率分别为甲硝唑 99.90 %和醋酸洗必泰 10 0 .6 %。相对标准差 (RSD)分别为甲硝唑 0 .38%和醋酸洗必泰0 .87%。结论 :使用该法 ,样品不经分离就可直接测定 ,方法简便快速、准确可靠 。Objective: Set up an analytical method for the determination of metronidazole and hibitane acetate in compound hibitane acetate solution. Methods: Using multicomponent analysis program, metronidazole and hibitane acetate in compound hibitane acetate solution were determined by UV spectrophotometry. Results: The calibration curve of metronidazole was in good linearity over the concentration range of 3～16 μg/ml at 319 nm. The calibration curve of hibitane acetate was in good linearity over the concentration range of 3～18 μg/ml at 253 nm. The average recoveries of metronidazole and hibitane acetate were 99.90% and 100.6% respectively, with RSD of 0.38% and 0.87% respectively (n=5). Conclusion: The sample could be determined directly by this method without any seperation step. This method is simple, rapid, accurate and reliable. It is suitable for the fast analysis in pharmacy.

关 键 词：紫外分光光度法 多组分分析程序 复方洗必泰 

分 类 号：R984[医药卫生—药品] R927.2[医药卫生—药学]