FGF和EGF对神经干细胞增殖及分化的影响  

Influence of fibroblast growth factor and epidermal growth factor on proliferation and differentiation of neural stem cells

作　　者：孙秀[1] 陈先文[1] 陈生弟[1] 

机构地区：[1]上海第二医科大学附属瑞金医院神经内科,上海200025

出　　处：《中国神经科学杂志》2000年第2期170-173,共4页

摘　　要：胚胎和成年哺乳动物脑内均存在神经干细胞。成纤维细胞生长因子 ( FGF)和表皮生长因子 ( EGF)对神经干细胞的增殖及分化有一定影响。 FGF和 EGF及其受体在胚胎期和成年期表达各异。 FGF和 EGF能促进神经干细胞增殖 ,在不同的条件下对分化的作用不同。A certain number of neural stem cells exist in the embryonic and adult mammalian brain.Fibroblast growth factor(FGF)and epidermal growth factor(EGF)have some effects on the proliferation and differentiation of neural stem cells.The expression of FGF and EGF and their receptors vary in the embryonic and adult brain.FGF and EGF can promote the proliferation of nerual stem cells,and differentially influence their differentiation under different conditions. [

关 键 词：FGF EGF 神经干细胞 细胞增殖 分化 

分 类 号：R338[医药卫生—人体生理学]