利用盐酸羟胺和不饱和酮酸酯的共轭加成反应合成异恶唑烷衍生物  

Conjugate Addition of Hydroxylamine to β,γ-unsaturated keto Esters: A Concise Synthesis of Isoxazolidine Derivatives

作　　者：刘亚男[1] 康泰然[1] 倪承燕[1] 何龙[1] 刘全忠[1] 

机构地区：[1]西华师范大学化学化工学院,四川南充637009

出　　处：《西华师范大学学报（自然科学版）》2012年第4期343-349,355,共8页Journal of China West Normal University(Natural Sciences)

基　　金：国家自然科学基金(20772097)资助项目

摘　　要：盐酸羟胺与不饱和酮酸酯的共轭加成反应已有报道.其共轭加成形成的半缩醛型化合物可用于合成高产率的异恶唑烷.作者探究了不饱和酮酸酯与盐酸羟胺在三乙胺的作用下形成恶唑烷衍生物的反应,常温条件下产率可达到98%.Conjugate addition of hydroxylamine hydrochloride to β, γ-unsaturated keto ester was reported. The conjugate adducts underwent a subsequent hemi-acetalisation forming the corresponding isoxazolidine in high yields. This article explored the reaction of β, γ-unsaturated keto seter with hydroxylamine hydrochloride catalyzed by triethylamine forming oxazolidine derivatives up to 98% yield at room temperature.

关 键 词：盐酸羟胺 不饱和酮酸酯 异恶唑烷 共轭加成 

分 类 号：O625.63[理学—有机化学]