青心酮对豚鼠离体气管条张力的影响及其机制  

Effect of 3,4-Dihydroxyacetophenone on Isolated Guinea-Pig Trachea and Its Mechanism of Action

作　　者：叶笃筠[1] 吴萍[1] 黄云峰[1] 洪志刚[1] 熊宗斌[1] 余尚斌[1] 

机构地区：[1]同济医科大学病理生理教研室,武汉430030

出　　处：《中草药》2000年第6期438-440,共3页Chinese Traditional and Herbal Drugs

摘　　要：采用气管条浴槽实验方法 ,观察青心酮 (DHAP)对离体豚鼠气管螺旋条张力的影响。结果发现 :DHAP明显松弛豚鼠的离体气管平滑肌 ;抑制由乙酰胆碱 (Ach)、组胺 (His)和氯化钾所致离体豚鼠气管平滑肌的收缩反应 ;对 5 -羟色胺 (5 - HT)诱发的由内钙释放引起的 相收缩和外钙内流所致的 相气管平滑肌收缩均有一定的抑制作用。 3.96× 10 - 5 m ol/L DHAP则仅抑制 相收缩。随着其剂量的增大 (>10 - 4 mol/L ) , 相收缩也被抑制 ,上述抑制作用均呈剂量依赖性 ;消炎痛对 DHAP松驰离体气管平滑肌作用无明显影响。提示 DHAP这一效应可能与其钙拮抗有关 。The Effects of 3,4 dihydroxyacetophenone (DHAP) on the tension of isolated guinea pig trachea spirals were studied by tension recording method It was found that DHAP relaxed the basal tension and markedly depressed the contractile response induced by the spasmogens (Ach, histamin, KCl, 5 HT) in a concentration dependent manner But indomethacin, a cyclooxygenase inhibitor, showed no influence on the relaxant effect of DHAP against the contraction of the spirals caused by Ach DHAP could abolish the contraction induced by 5 HT both in phase 1 (release of intracellular calcium) and phase 2 (entrance of extracellular calcium) These results suggested that the relaxant effect of DHAP on isolated guinea pig trachea spirals may be resulted from a decreased concentration of intracellular calcium

关 键 词：青心酮 张力 肺疾病 呼吸道疾病 豚鼠 

分 类 号：R259.602[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]