补充纳米生血铁剧烈运动大鼠肝脏铁调素mRNA的表达  

Effects of “iron nutrient in nanometer” supplementation on hepatic hepcidin mRNA expression after strenuous exercise in rats

作　　者：潘小玲[1] 廖春海[1] 庞阳康[1] 杨小平 

机构地区：[1]广东医学院体育教学部,广东省湛江市524023 [2]湛江市药品检验所,广东省湛江市524048

出　　处：《中国组织工程研究》2012年第43期8013-8017,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:如何提高高强度运动应激条件下人体补铁的效益,维持机体铁稳态,快速升高血色素水平成为广大教练员、体育科学研究者关注的焦点。目的:观察补充纳米生血铁对剧烈运动大鼠肝脏铁调素mRNA表达的影响。方法:将60只SD大鼠随机分为4组:安静状态补充安慰剂组、高强度运动补充安慰剂组、安静灌胃补充纳米生血铁组、高强度运动灌胃补充纳米生血铁组。结果与结论:与安静状态补充安慰剂组比较,高强度运动补充安慰剂组大鼠肝脏铁调素mRNA表达增加、血清铁浓度减低、血清总铁结合力增加、转铁蛋白饱和度减低、血色素浓度减低;安静灌胃补充纳米生血铁组、高强度运动灌胃补充纳米生血铁组大鼠肝脏铁调素mRNA表达均减少,血清铁浓度、血清总铁结合力及血清转铁蛋白饱和度均增加,安静灌胃补充纳米生血铁组大鼠血色素浓度增加,高强度运动灌胃补充纳米生血铁组大鼠血色素浓度减低,但减少程度低于高强度运动补充安慰剂组。表明补充纳米生血铁可显著抑制大强度递增负荷剧烈运动后大鼠肝脏铁调素mRNA的表达,增加肠道对铁的吸收,提升血清铁和血色素水平,减轻运动性血色素减少程度。BACKGROUND： It is a focus that how to improve the benefit of iron supplement in the human body at high intensity exercise, remain body iron homeostasis and increase hemoglobin level. OBJECTIVE： To investigate the effects of ＂iron nutrient in nanometer＂ supplementation on the expression of hepatic hepcidin mRNA after high intensity exercise in rats. METHODS： Totally 60 healthy male SD rats were randomly divided into four groups： no-exercise group A （were fed with placebo, n=15）, exercise group B （were fed with placebo, n=15）, no-exercise group C （＂iron nutrient in nanometer＂ supplementation with lavage method, n=15） and exercise group D （＂iron nutrient in nanometer＂ supplementation with lavage method, n=15）. RESULTS AND CONCLUSION： Compared with group A, the expression of hepatic hepcidin mRNA in rats was increased but the iron concentration was decreased, and total iron binding capacity in serum was increased; transferring saturation was reduced and the concentration of hemoglobin was decreased in group B. But The expression of hepatic hepcidin mRNA was reduced in group C and group D, and the concentration of serum iron increased, total iron binding capacity in serum, and transferring saturation were increased in group C and group D; the concentration of hemoglobin was decreased in group C and group D, but the decreasing degree in group C was lower than that in group D. These findings suggest that ＂iron nutrient in nanometer＂ supplementation can significantly inhibit the expression of hepatic hepcidin mRNA after high intensity load exercise in rats, and increase the absorption for ＂iron nutrient in nanometer＂ supplementation; besides, it can improve the level of serum iron and hemoglobin and relieve the decreasing degree of exercise-induced hemoglobin.

关 键 词：纳米生血铁 剧烈运动 铁调素mRNA 血色素 大鼠 

分 类 号：R318[医药卫生—生物医学工程]